DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and RCK2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_013349.1	Gene:	RCK2 / 850950	SGDID:	S000004238	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	469	Identity:	140/469 - (29%)
Similarity:	207/469 - (44%)	Gaps:	119/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ELNKQVSIEEK----YNLHGLLGTGAFSEV-RLAESKDSPGEHF-------AVKIIDKKAL---- 68
            |:.::..:|:|    |.|...:|.||||:| |...:|:|..|..       |:|:|.|..|
Yeast   148 EIPEKSFLEQKELIGYKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSIN 212

  Fly    69 -------KGKE-------ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVY 119
                   |||:       :.:..|:.:.:..||.     |        ..||..::..|..|..|
Yeast   213 GDHRKKDKGKDSTKTSSRDQVLKEVALHKTVSAG-----C--------SQIVAFIDFQETDSYYY 264

  Fly   120 LVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLY-------- 176
            ::.||:||||:|..||....::|..:.|:|:|:..||.:||..||||||:||||||:
Yeast   265 IIQELLTGGEIFGEIVRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRS 329

  Fly   177 ------YSPDDDSK-----------------IMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQ 218
                  .|.|..:|                 :.::||||||...|....|.|||.||.||||:..
Yeast   330 IKPKLRKSDDPQTKADEGIFTPGVGGGGIGIVKLADFGLSKQIFSKNTKTPCGTVGYTAPEVVKD 394

  Fly   219 KPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLM 283
            :.|...||:|.||.:.|.:|||:||||||....|..:|.:|::.|..|:|||||..||:.:..|:
Yeast   395 EHYSMKVDMWGIGCVLYTMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLL 459

  Fly   284 CVTVEKRYTCKQALGHAWISGNEA------SSRNIHGTVSEQL---KKNF-------------AK 326
            .:...|||...|.|...|::..:.      ||:...|| ||:.   ||.|             |.
Yeast   460 ELEPSKRYDIDQFLDDPWLNTFDCLPKEGESSQKKAGT-SERRHPHKKQFQLFQRDSSLLFSPAA 523

  Fly   327 SRWKQAYYAATVIRQMQ--RMAL--------------NSNSNANFDSSNSSNQDSTTPTAATGAW 375
            ...:.|:.....:::.:  ||..              :|.|.|..|.....|....|..
Yeast   524 VAMRDAFDIGNAVKRTEEDRMGTRGGLGSLAEDEELEDSYSGAQGDEQLEQNMFQLTLD------ 582

  Fly   376 TSNVLSSQQSVQSH 389
            ||.:|..::.||.:
Yeast   583 TSTILQRRKKVQEN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	114/334 (34%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	112/327 (34%)
RCK2	NP_013349.1	STKc_RCK1-like	161..478	CDD:270998	112/329 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910