DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and CMK1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_116669.1	Gene:	CMK1 / 850568	SGDID:	S000001910	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	411	Identity:	150/411 - (36%)
Similarity:	222/411 - (54%)	Gaps:	62/411 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKDS-GKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALK 69
            ::|| ||.|..:....:||     :||.....||.|.|..||.|::.:: ||..||||:.|||||
Yeast    16 EEDSEGKMAHVQPASYVNK-----KKYVFGKTLGAGTFGVVRQAKNTET-GEDVAVKILIKKALK 74

  Fly    70 GKE---ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELF 131
            |.:   |:|.:|:.:|:               ||.|||||...:.:|.|.|.|::.:|..|||||
Yeast    75 GNKVQLEALYDELDILQ---------------RLHHPNIVAFKDWFESKDKFYIITQLAKGGELF 124

  Fly   132 DRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK-- 194
            |||::||.:||:||..::.:||.||.|||.|.:||||||||||||....|:|.::::|||::|
Yeast   125 DRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRL 189

  Fly   195 MEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKG 259
            ..|..::....|:.||||||||.|..:||..|:||||||:|.|||||..|..|...:...:...|
Yeast   190 KSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTG 254

  Fly   260 DF--EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKK 322
            ::  :|..||||.:|..||.||...:.:...||.|..:.|...||...|..:.|:...:.|.|.
Yeast   255 EYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLEDPWIICTELKTHNLLPGLKEGLD- 318

  Fly   323 NFAKSRWKQAYYAATVIRQMQRMALN-------------SNSNANFDSSNSSNQDSTTPTAATGA 374
              |:.:::.:         ::|:.||             :.|:::||..:.:| .|..|..||.
Yeast   319 --ARQKFRNS---------VERVRLNMKIQKLRDLYLEQTESDSDFDEGSQAN-GSVPPLKATD- 370

  Fly   375 WTSNVLSSQQSVQSHAQEMNK 395
                  :||.|.:...:|.:|
Yeast   371 ------TSQLSKKLSEEEQSK 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	120/280 (43%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	119/277 (43%)
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	120/277 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I580
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I708
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		mtm9194
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
TreeFam	0	0.000	Not matched by this tool.
	10	9.890