DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Kalrn

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_038944566.1	Gene:	Kalrn / 84009	RGDID:	621865	Length:	2989	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	92/308 - (29%)
Similarity:	144/308 - (46%)	Gaps:	37/308 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AKDLKELNKQVSIEEKYNLHGLLGTGAFSEVR----LAESKDSPGEHFAVKIIDKKALKGKEESL 75
            |.|...::.:.:.:..|.....:|.|.||.|:    .|..||     .|||.:.|| :|.||::
  Rat  2671 AADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKD-----VAVKFVSKK-MKKKEQA- 2728

  Fly    76 ENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSY 140
            .:|..:|:               .|.||..|.|.:|||..:...|::||:..|.|.|.::.....
  Rat  2729 AHEAALLQ---------------HLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDEL 2778

  Fly   141 TEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMA--- 202
            .|:..:..||.|:||:.|:|...|.|.|:||||||.     |.:|.:....|..:||:..::
  Rat  2779 MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLI-----DLRIPVPRVKLIDLEDAVQISGHF 2838

  Fly   203 ---TACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFD 264
               ...|.|.:.||||:...|.....|:|||||::|::|.|..||.||:.......:.:.||.|.
  Rat  2839 HIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFP 2903

  Fly   265 SPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNI 312
            ..|:..:|.:|:.||..::.....:|.|....|.|.|:..:..|...|
  Rat  2904 HEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKI 2951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	87/283 (31%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	87/280 (31%)
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103
		SPEC	314..539	CDD:238103
		SPEC	540..769	CDD:238103
		SPEC	894..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1287..1457	CDD:238091
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060
		SH3_Kalirin_1	1652..1711	CDD:212786
		SH3-RhoG_link	1708..1892	CDD:406906
		RhoGEF	1935..2104	CDD:395496
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061
		SH3_Kalirin_2	2327..2385	CDD:212787
		Ig strand A	2466..2469	CDD:409353
		I-set	2474..2568	CDD:400151
		Ig strand A'	2482..2485	CDD:409353
		Ig strand B	2491..2498	CDD:409353
		Ig strand C	2504..2512	CDD:409353
		Ig strand C'	2515..2517	CDD:409353
		Ig strand D	2523..2532	CDD:409353
		Ig strand E	2534..2538	CDD:409353
		Ig strand F	2547..2555	CDD:409353
		Ig strand G	2558..2568	CDD:409353
		FN3	2572..2663	CDD:238020
		STKc_Kalirin_C	2693..2940	CDD:271017	86/273 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900