DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and CAMK2G

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_016872205.1	Gene:	CAMK2G / 818	HGNCID:	1463	Length:	615	Species:	Homo sapiens

Alignment Length:	415	Identity:	150/415 - (36%)
Similarity:	213/415 - (51%)	Gaps:	58/415 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            :.|.|...||.||||.||....|.|..| :|.|||:.|.|..:: :.||.|.|:.|
Human    12 DDYQLFEELGKGAFSVVRRCVKKTSTQE-YAAKIINTKKLSARDHQKLEREARICR--------- 66

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|||||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|.||||:|:
Human    67 ------LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            ::|:..:|||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.:.
Human   126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGEQQAWFGFAGTPGYLSPEVLRKD 189

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            ||||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||:.|..::.
Human   190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254

  Fly   285 VTVEKRYTCKQALGHAWISGNEA------------------SSRNIHGTV--SEQLKKNFAKSRW 329
            :...||.|..|||.|.|:.....                  :.|.:.|.:  :..:.:||:..|.
Human   255 INPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQ 319

  Fly   330 KQ-----AYYAATVIRQMQRMALNSNSNANFDSSNSS----------NQDSTTPTAATGAWTSNV 379
            ..     |..||.:..|..:..||..|:.......||          |::|....|...|.....
Human   320 SSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTA 384

  Fly   380 LSSQQSVQSHAQEMNKSGGSTNAAS 404
            :..|.:|..:|.:..|  |||.:.:
Human   385 MEPQTTVVHNATDGIK--GSTESCN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	124/275 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	124/274 (45%)
CAMK2G	XP_016872205.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920