Protein Alignment CaMKI and CAMK2A

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_057065.2
• Gene: CAMK2A / 815
• HGNCID: 1460
• Length: 489
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 141/371 - (38%)
• Similarity: 198/371 - (53%)
• Gaps: 22/371 - (5%)

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            |:|.|...||.||||.||.. .|...|:.:|.|||:.|.|..:: :.||.|.|:.|
Human    11 EEYQLFEELGKGAFSVVRRC-VKVLAGQEYAAKIINTKKLSARDHQKLEREARICR--------- 65

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|||||:|.::..::...||:.:||||||||:.||.:..|:|.||||.|:||||||.
Human    66 ------LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            :.|:.|||||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.:.
Human   125 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVEGEQQAWFGFAGTPGYLSPEVLRKD 188

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            ||||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||..|..::.
Human   189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 253

  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNS 349
            :...||.|..:||.|.|||.....:..:|...:....|.|...|..:.....|::.........|
Human   254 INPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKS 318

  Fly   350 NSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNK 395
            ..|...|........|:.....:...|:..:..:.: :...||:.|
Human   319 GGNKKSDGVKKRKSSSSVQLMESSESTNTTIEDEDT-KVRKQEIIK 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	125/275 (45%)
CAMK2A	NP_057065.2	STKc_CaMKII	11..302	CDD:270988	132/307 (43%)
		CaMKII_AD	357..484	CDD:285524	3/7 (43%)