DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and CAMK4

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens

Alignment Length:	346	Identity:	146/346 - (42%)
Similarity:	217/346 - (62%)	Gaps:	35/346 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKI----IDKKALKGKEESLENEIRVLRRFS 86
            ::.:.:.:...||.||.|.|...:.|.:. :.:|:|:    :|||.::       .||.||
Human    41 ALSDFFEVESELGRGATSIVYRCKQKGTQ-KPYALKVLKKTVDKKIVR-------TEIGVL---- 93

  Fly    87 ANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQ 151
                       .||:||||::|.|.:|..:::.||:||||||||||||||||.|:|:||:..::|
Human    94 -----------LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQ 147

  Fly   152 ILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK-MEDSGIMATACGTPGYVAPEV 215
            |||||.|:||.|:||||||||||||.:|..|:.:.|:|||||| :|...:|.|.||||||.|||:
Human   148 ILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEI 212

  Fly   216 LAQKPYGKAVDVWSIGVISYILLCGYPPFYDE-NDANLFAQILKGDFEFDSPYWDEISESAKHFI 279
            |....||..||:||:|:|:||||||:.||||| .|..:|.:||..::.|.||:|||:|.:||..:
Human   213 LRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLV 277

  Fly   280 KNLMCVTVEKRYTCKQALGHAWISGNEASSRNIH-GTVSEQLKKNFAKSRWKQAYYAATVIRQMQ 343
            :.|:.:..:||.|..|||.|.|::|..|:.  :| .|..::|::..|:.:.|.|..|...   ..
Human   278 RKLIVLDPKKRLTTFQALQHPWVTGKAANF--VHMDTAQKKLQEFNARRKLKAAVKAVVA---SS 337

  Fly   344 RMALNSNSNANFDSSNSSNQD 364
            |:...|:|:.:...|:.:::|
Human   338 RLGSASSSHGSIQESHKASRD 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	131/279 (47%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	131/276 (47%)
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	141/317 (44%)
		Pkinase	46..300	CDD:278497	131/276 (47%)
		Autoinhibitory domain	305..321		4/17 (24%)
		PP2A-binding	306..323		3/18 (17%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720