DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Dapk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_036014050.1	Gene:	Dapk1 / 69635	MGIID:	1916885	Length:	1464	Species:	Mus musculus

Alignment Length:	375	Identity:	124/375 - (33%)
Similarity:	192/375 - (51%)	Gaps:	34/375 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GAFSEVRLAESKDSPGEHFAVKIIDKKALKG-----KEESLENEIRVLRRFSANHFDGKCLNGTR 99
            |.|:.|:....| |.|..:|.|.|.|:..|.     ..|.:|.|:.:|:               .
Mouse    44 GQFAVVKKCREK-STGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK---------------E 92

  Fly   100 LTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGV 164
            :.|||::.|.|.||:|:.|.|::|||.||||||.:.||.|.||::|:..::|||..|.|:|...:
Mouse    93 IRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILSGVYYLHSLQI 157

  Fly   165 VHRDLKPENLLYYSPD-DDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDV 227
            .|.||||||::....: ...:|.|.||||: |::.........|||.:||||::..:|.|...|:
Mouse   158 AHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADM 222

  Fly   228 WSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYT 292
            ||||||:||||.|..||..:......|.:...:::|:..::...|..||.||:.|:....:||.|
Mouse   223 WSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRMT 287

  Fly   293 CKQALGHAWI---SGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNSNSNAN 354
            .:.:|.|.||   ...:|.||.......|:.||..|:.:|||:....::.:::.|..| |.||.:
Mouse   288 IQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFL-SRSNMS 351

  Fly   355 FDSSNSS--NQDSTTPTAATGAWTSNVLSSQQ----SVQSH-AQEMNKSG 397
            ...|:.:  .:||....|...|...:.:...|    |:.|: ..:.||.|
Mouse   352 VARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSSYDVNQPNKHG 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	96/267 (36%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	96/268 (36%)
Dapk1	XP_036014050.1	PKc_like	35..297	CDD:419665	96/268 (36%)
		Ank_2	<360..431	CDD:423045	10/42 (24%)
		ANK repeat	400..431	CDD:293786	1/2 (50%)
		Ank_4	401..453	CDD:372654	1/1 (100%)
		ANK repeat	434..464	CDD:293786
		Ank_2	450..>661	CDD:423045
		ANK repeat	466..497	CDD:293786
		ANK repeat	499..530	CDD:293786
		ANK repeat	532..563	CDD:293786
		PLN03192	<537..790	CDD:215625
		ANK repeat	565..596	CDD:293786
		ANK repeat	598..629	CDD:293786
		ANK repeat	631..660	CDD:293786
		Death_DAPK1	1330..1415	CDD:260052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900