DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and STK33

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	376	Identity:	118/376 - (31%)
Similarity:	190/376 - (50%)	Gaps:	56/376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDK-KALKGKEESLENEIRVLRRFSANH 89
            :|||.|....:||.|:|..|..|..|::..: :|:|.::| ||.....:.||.|:.:|:
Human   111 AIEEIYTFGRILGKGSFGIVIEATDKETETK-WAIKKVNKEKAGSSAVKLLEREVNILK------ 168

  Fly    90 FDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILE 154
                     .:.|.:|:.|.:.:|...|:||||||...|||.:.:..||.::|.:...:|:.:..
Human   169 ---------SVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLAS 224

  Fly   155 AVDYMHEQGVVHRDLKPENLLYYSP--DDDSK----IMISDFGLSKMEDS---GIMATACGTPGY 210
            |:.|:|...:||||||.||::..|.  ||:::    |.::||||:..:.|   .::...||||.|
Human   225 AIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIY 289

  Fly   211 VAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESA 275
            :||||::...|.:..|:|||||:.|:||.|.|||...::..||..|.||:..|::..|:.||:.|
Human   290 MAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCA 354

  Fly   276 KHFIKNLMCVTVEKRYTCKQALGHAWISGNEASS-----------------RNIHGTVSEQLKKN 323
            |..:|.||.|....|.|.|:.|.:.|::||:.||                 .::....:|:..|.
Human   355 KSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKP 419

  Fly   324 FAKSRWK---------QAYYAATVIRQMQRMALN----SNSNANFDSSNSS 361
            ..:.:.|         .|.|.:....:.|..|..    :.|..|||..:||
Human   420 STEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	100/283 (35%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	97/280 (35%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91
		STKc_STK33	114..381	CDD:270999	98/282 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468		11/65 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820