DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and dclk2a

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001128593.1	Gene:	dclk2a / 572548	ZFINID:	ZDB-GENE-050420-170	Length:	810	Species:	Danio rerio

Alignment Length:	398	Identity:	155/398 - (38%)
Similarity:	225/398 - (56%)	Gaps:	52/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHF 90
            :|.:||.:..::|.|.|:.|:....: |.|:.||:|||||...:|||..:|||:.|||
Zfish   415 TILDKYKIGKVIGDGNFAVVKECVER-STGKEFALKIIDKNKCRGKEHLIENEVAVLR------- 471

  Fly    91 DGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEA 155
                    |:.||||:.|:|..:..:::|||||||.||:|||.|.....|||||||.::..:..|
Zfish   472 --------RVKHPNIIMLIEEVDTPAELYLVMELVKGGDLFDAITSSTKYTEKDASVMVFDLAAA 528

  Fly   156 VDYMHEQGVVHRDLKPENLLYYS-PDDDSKIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQK 219
            :.|:|...:||||:||||||... |:....:.:.||||:.:.: |.:.|.||||.|||||::|:.
Zfish   529 LKYLHRMCIVHRDIKPENLLVCEYPNGTKSLKLGDFGLATVVE-GPLYTVCGTPTYVAPEIIAES 592

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDEND--ANLFAQILKGDFEFDSPYWDEISESAKHFIKNL 282
            .||..||:|:.|||:||||||:|||..||:  .:||.|||.|..||.||:||.||:|||..|.::
Zfish   593 GYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILLGHLEFPSPFWDNISDSAKELIGHM 657

  Fly   283 MCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAA----------- 336
            :.|.||.|||.:..|.|.|::.:.|...|:...|:.:|||:| .|..||:..:|
Zfish   658 LQVNVEARYTAEDVLSHPWVTEDAAMENNMKMEVAGKLKKHF-NSVQKQSNTSAGVSVIMNTALD 721

  Fly   337 --TVIRQMQRMALN--------SNSN-----ANFDSSNSSNQDSTTPTAATGAWTSN-----VLS 381
              |:....:|...|        |::|     :|...|:..::||.:......|.::|     .|.
Zfish   722 KETIQLSHRRQDRNPPRPEKRPSSTNPERRRSNRGRSSVQSEDSRSAAPIEPATSANPSAPAALP 786

  Fly   382 SQQSVQSH 389
            |..|.|.|
Zfish   787 SDPSPQFH 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	127/276 (46%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	125/273 (46%)
dclk2a	NP_001128593.1	DCX	59..149	CDD:214711
		DCX	186..274	CDD:214711
		STKc_DCKL2	418..676	CDD:271086	126/274 (46%)
		S_TKc	420..677	CDD:214567	125/273 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820