DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and PSKH1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_006733.1	Gene:	PSKH1 / 5681	HGNCID:	9529	Length:	424	Species:	Homo sapiens

Alignment Length:	331	Identity:	146/331 - (44%)
Similarity:	209/331 - (63%)	Gaps:	28/331 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFD 91
            :..||::..|:|.|:||.|...|.: :..:.:|:|:|:.|..:|: |..|:|:||||
Human    94 VTAKYDIKALIGRGSFSRVVRVEHR-ATRQPYAIKMIETKYREGR-EVCESELRVLR-------- 148

  Fly    92 GKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAV 156
                   |:.|.||:||:|.:|.:.:||:||||.|||||||||:.|||:||:||:.:::.:|:.|
Human   149 -------RVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGV 206

  Fly   157 DYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS---KMEDSGIMATACGTPGYVAPEVLAQ 218
            .|:|..|:.||||||||||||.|..||||:|:||||:   |..|..:|.|.||||.|:|||||.:
Human   207 RYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVR 271

  Fly   219 KPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLM 283
            |||..:||:|::|||:||||.|..||.|:|...|:.|||:|.:.:....|..:|..||.||..|:
Human   272 KPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336

  Fly   284 CVTVEKRYTCKQALGHAWISGNEASS--RNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMA 346
            .|....|.|..|||.|.|:....|||  :|:|.::|:.|.|. |.||.:     :|...|..|.:
Human   337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKR-ASSRCQ-----STKSAQSTRSS 395

  Fly   347 LNSNSN 352
            .::.||
Human   396 RSTRSN 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	129/276 (47%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	128/273 (47%)
PSKH1	NP_006733.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..80
		STKc_PSKH1	96..355	CDD:270989	129/275 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..407		8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820