DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and pnck

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_021334045.1	Gene:	pnck / 567480	ZFINID:	ZDB-GENE-081105-127	Length:	333	Species:	Danio rerio

Alignment Length:	345	Identity:	187/345 - (54%)
Similarity:	248/345 - (71%)	Gaps:	16/345 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVL 82
            |::|.|:..|...|.|...||.|:|||||:|:.:.:. :..|||.|.|:||||||..||||:.||
Zfish     4 LRDLRKKDDINAVYELKEKLGEGSFSEVRVAQHRCTQ-KLVAVKCIRKRALKGKESMLENEVAVL 67

  Fly    83 RRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASH 147
            |               |:.|.|||.|.||:|..:|:||||.|:|||||.:||:|:|||||||||.
Zfish    68 R---------------RINHENIVSLEETFETPTKLYLVMTLLTGGELLNRILERGSYTEKDASR 117

  Fly   148 LIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMATACGTPGYVA 212
            :|.|:|:||.|:|:.||||||||||||::.:|.:||||:||||||||||:.|.::||||||.|||
Zfish   118 VIYQVLQAVKYLHQLGVVHRDLKPENLIFETPLEDSKIVISDFGLSKMEEQGALSTACGTPAYVA 182

  Fly   213 PEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKH 277
            ||:|.||.|||.||:|:||||::|||||||||||:||..|:..|:|.::|||||||::||:|||.
Zfish   183 PELLQQKTYGKEVDLWAIGVITFILLCGYPPFYDDNDTQLYKLIIKAEYEFDSPYWNDISDSAKD 247

  Fly   278 FIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQM 342
            ||.:|:.....||:.|:||..|.||||..|..|||||:||.|::||||||.||:|:.|..::..:
Zfish   248 FIVHLLQKDPAKRFNCEQASQHPWISGGAALDRNIHGSVSAQIQKNFAKSHWKRAFNATIIVHHL 312

  Fly   343 QRMALNSNSNANFDSSNSSN 362
            .:.|.....:....|::..|
Zfish   313 TKKAHPGEDDEGNQSTSIGN 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	158/273 (58%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	157/270 (58%)
pnck	XP_021334045.1	PKc_like	13..289	CDD:328722	170/291 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574796
Domainoid	1	1.000	318	1.000	Domainoid score	I1229
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm25043
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.710