DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CaMKI and spegb

DIOPT Version :9

Sequence 1:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster
Sequence 2:XP_021334681.1 Gene:spegb / 563174 ZFINID:ZDB-GENE-081104-517 Length:3608 Species:Danio rerio


Alignment Length:379 Identity:111/379 - (29%)
Similarity:188/379 - (49%) Gaps:53/379 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 KDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGK 71
            ||...:.:|..|:::.:   :.:.|::|..:|.||||.|:....|....| :|.|.|..:| |.|
Zfish  1641 KDDPMEDEASILRKMRR---LTDYYDVHKEIGRGAFSYVKRVIQKAGKLE-YAAKFISARA-KRK 1700

  Fly    72 EESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVE 136
            ..:| .|:.:|     :|.|          |..|:...:.:|.|:.|.::.|| ...||.||:.:
Zfish  1701 ASAL-RELNIL-----SHLD----------HERILYFHDAFEKKNAVIIITEL-CHEELLDRLTK 1748

  Fly   137 KGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFG--LSKMEDSG 199
            |.:..|.:....:||:||.::|:|:..::|.|:||:|:|......| :|.|.|||  :..|.|. 
Zfish  1749 KSTILESEIRSSVRQLLEGINYLHQLDILHLDIKPDNILMADHSSD-QIRICDFGNAVKFMPDE- 1811

  Fly   200 IMATAC--GTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFE 262
              |..|  |||.:||||::.|.|..||.|:|.|||::|:.|.|..||..|||.:....|...:..
Zfish  1812 --AQYCKYGTPEFVAPEIVNQTPVSKATDIWPIGVLTYLCLTGVSPFAGENDRSSVLNIRNYNVA 1874

  Fly   263 FDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISG-NEASSRNIHGTVSEQLKKNFAK 326
            |:...:.::...||.|:..|: |....|....:.|.|.|... |:..|.:     :|.|||..::
Zfish  1875 FEESMFTDLCHEAKGFVIKLL-VADRLRPDANECLRHPWFKTLNKGKSIS-----TESLKKFLSR 1933

  Fly   327 SRWKQ---AYYAATVIRQMQRMALNSNSNAN-------------FDSSNSSNQD 364
            .:|::   :|.:..|:|.:..:..:|:|:.:             ..||:.|::|
Zfish  1934 RKWQRSLISYKSKMVMRSVPELLDDSSSHISIAVPRHLKKGSPPLSSSSDSDED 1987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 90/277 (32%)
S_TKc 31..302 CDD:214567 90/274 (33%)
spegbXP_021334681.1 I-set 55..137 CDD:254352
DUF4045 <228..687 CDD:330572
I-set 781..870 CDD:254352
I-set 928..1018 CDD:254352
I-set 1029..1117 CDD:254352
I-set 1123..1212 CDD:254352
I-set 1249..1338 CDD:254352
FN3 1343..1436 CDD:238020
Ig <1479..1541 CDD:325142
I-set 1545..1634 CDD:254352
PKc_like 1659..1913 CDD:328722 90/277 (32%)
I-set 2861..2949 CDD:254352
FN3 2955..3044 CDD:238020
PKc_like 3296..3552 CDD:328722
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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