DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and camk2b1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_021331894.1	Gene:	camk2b1 / 562064	ZFINID:	ZDB-GENE-030131-9588	Length:	693	Species:	Danio rerio

Alignment Length:	424	Identity:	155/424 - (36%)
Similarity:	225/424 - (53%)	Gaps:	68/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            ::|.|:..||.||||.||.. .|.|.|:.:|.|||:.|.|..:: :.||.|.|:.|
Zfish    11 DEYQLYEELGKGAFSVVRRC-VKLSTGQEYAAKIINTKKLSARDHQKLEREARICR--------- 65

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|||||:|.::..::...||:.:||||||||:.||.:..|:|.||||.|:||||||.
Zfish    66 ------LLKHPNIVRLHDSISEEGFHYLLFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            :.|:.|||||||||||||..|...::.:.::||||: :|..|....   ..|||||::||||.::
Zfish   125 HCHQMGVVHRDLKPENLLLASKCKNAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLRKE 188

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            .|||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||:.|..::.
Zfish   189 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 253

  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIH--GTVSEQLKKNFAKSRWKQAYY------------- 334
            :...||.|.::||.|.|:......:..:|  .|| |.|||..|:.:.|.|..
Zfish   254 INPAKRITAQEALKHPWVCQRSTVASMMHRQETV-ECLKKFNARRKLKGAILTTMLVSRNFSVGS 317

  Fly   335 ----------------------AATVIRQMQRMALNSNSNANFDSSNSSNQ-----DSTTPTAAT 372
                                  .|.::.|..:..||..::.....|:|:.|     :||..:..|
Zfish   318 RQTTAPASVTAAAAAVAAAAGTTAGLVEQAAKTLLNKKADVKKRKSSSTIQYMPQTNSTKNSIVT 382

  Fly   373 ---GAWTSNVLSSQQSVQSHAQE-MNKSGGSTNA 402
               |...|..|.:|.:|..:|.: :.:|..|:||
Zfish   383 SPKGNLPSPALEAQTTVIHNAVDGIKESSDSSNA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	124/275 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	124/274 (45%)
camk2b1	XP_021331894.1	STKc_CaMKII	11..302	CDD:270988	134/308 (44%)
camk2b1	XP_021331894.1	CaMKII_AD	561..688	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920