DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and mylk3

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001099057.1	Gene:	mylk3 / 561635	ZFINID:	ZDB-GENE-030131-3497	Length:	715	Species:	Danio rerio

Alignment Length:	369	Identity:	121/369 - (32%)
Similarity:	190/369 - (51%)	Gaps:	52/369 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DSGKKAKAKDLKELN-----------------------KQVSIEEKY--NLHGLLGTGAFSEV-R 46
            |..:|:||..|:::.                       |||.|...|  |...:||.|.|.:| :
Zfish   356 DEDEKSKAAPLRKVESTLLIIDDSPPLPAPFDHRIVSAKQVPINSYYAVNPVEVLGGGRFGQVHK 420

  Fly    47 LAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLET 111
            .||.  |.|...|.|||..:.:|.::| ::|||.|:               .:|.|.|::||.:.
Zfish   421 CAEL--SSGLTLAAKIIKVRGMKERDE-VKNEIGVM---------------NQLNHVNLIQLYDA 467

  Fly   112 YEDKSKVYLVMELVTGGELFDRIVEKGSY--TEKDASHLIRQILEAVDYMHEQGVVHRDLKPENL 174
            :|.::.:.|:||.|.|||||:||::: ||  ||.||....|||.|.|.|:|:|.::|.||||||:
Zfish   468 FESRTNLTLIMEYVEGGELFERIIDE-SYQLTELDAIVFTRQICEGVQYLHQQYILHLDLKPENI 531

  Fly   175 LYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILL 238
            |..: ...::|.|.||||: |......:....|||.::||||:.........|:||:|||:|:||
Zfish   532 LCVN-STGNQIKIIDFGLARKYRPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVITYMLL 595

  Fly   239 CGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWIS 303
            .|..||..:|||.....||...:|||:..::.:||.||.||.:|:......|.:....:.|:|::
Zfish   596 SGLSPFMGDNDAETMNNILHAKWEFDTEAFENVSEEAKDFISSLLVSAKCSRLSASGCMKHSWLN 660

  Fly   304 GNEASSRNIHGTVSEQL---KKNFAKSRWKQAYYAATVIRQMQR 344
            ..|..::.....:..|:   :...|..:||:.:||.....:::|
Zfish   661 NLEDKAKMYKVRLKSQMMLQRYLVAHRQWKKHFYAVAAANRLKR 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	104/279 (37%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	103/276 (37%)
mylk3	NP_001099057.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..114
		STKc_MLCK3	399..659	CDD:271094	103/279 (37%)
		S_TKc	407..659	CDD:214567	101/271 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900