DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and trioa

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_021323750.1	Gene:	trioa / 557667	ZFINID:	ZDB-GENE-060503-334	Length:	3115	Species:	Danio rerio

Alignment Length:	313	Identity:	96/313 - (30%)
Similarity:	154/313 - (49%)	Gaps:	29/313 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKA 67
            :.|....|.:...||        :.|..|.....||.|.||.|:..:.:.|. ...|||.::||.
Zfish  2793 VLGTTSDGIRVMWKD--------NFESFYTEVAELGRGRFSVVKRCDQRGSK-RTVAVKFVNKKL 2848

  Fly    68 LKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFD 132
            :  |.:.:.:|..||:               ||.||::|:||:|:|..|...||:|:...|.|.|
Zfish  2849 M--KRDQVTHEFSVLQ---------------RLQHPHLVRLLDTFETSSSYALVLEMSDQGRLLD 2896

  Fly   133 RIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFG-LSKME 196
            .||..|:.||:..:..:|.||||:.|:|...:||.|||||||:.........:.::||| ..::.
Zfish  2897 YIVSWGNLTEEKVAFYLRDILEALQYLHNCRIVHLDLKPENLVVEQSPSQPLVKLTDFGDAVQLN 2961

  Fly   197 DSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDF 261
            .:..:....|:|.:.|||::...|...:.|:||:||::|::|.|..||.||:.......|.:.||
Zfish  2962 STPYVHPLLGSPEFAAPELVLGDPVSLSSDLWSLGVLTYVMLSGASPFLDESVEETCLNICRLDF 3026

  Fly   262 EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWI--SGNEASSRNI 312
            .|...|:..:|::|:.|:..|:.:...||......|...|:  .|...|:..|
Zfish  3027 SFPDDYFQGVSQAARDFMCLLLRMEPSKRPPATSCLQEPWLRAGGGRRSAECI 3079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	88/274 (32%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	87/271 (32%)
trioa	XP_021323750.1	SEC14	61..199	CDD:214706
		SPEC	212..447	CDD:238103
		SPEC	343..589	CDD:238103
		SPEC	590..806	CDD:238103
		SPEC	810..1037	CDD:238103
		SPEC	931..1160	CDD:238103
		SPEC	1166..1266	CDD:197544
		RhoGEF	1316..1488	CDD:238091
		PH1_Kalirin_Trio_like	1495..1627	CDD:270060
		SH3_Kalirin_1	1695..1754	CDD:212786
		SH3-RhoG_link	1752..2000	CDD:318750
		RhoGEF	2007..2180	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2185..2324	CDD:270061
		Atrophin-1	<2364..2523	CDD:331285
		SH3_Kalirin_2	2570..2628	CDD:212787
		I-set	2702..2793	CDD:254352	96/313 (31%)
		PKc_like	2805..3067	CDD:328722	90/287 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900