DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and camk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001016269.1	Gene:	camk1 / 549023	XenbaseID:	XB-GENE-1017139	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	228/409 - (55%)
Similarity:	283/409 - (69%)	Gaps:	48/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDK 65
            |||.....|.|| :|:|::::         |....:|||||||||.|||.|.:. :..|:|.|.|
Frog     1 MPLDEDGPSWKK-RAEDIRDI---------YEFREVLGTGAFSEVVLAEEKKTQ-KLVAIKCIPK 54

  Fly    66 KALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGEL 130
            |||:|||.|:||||.|||               ::.|.|||.|.:.||.:|.:||:|:||:||||
Frog    55 KALEGKETSIENEIAVLR---------------KIKHANIVSLEDIYESRSHLYLIMQLVSGGEL 104

  Fly   131 FDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKM 195
            ||||||||.|||||||.||:|||:||.|:|:.|:||||||||||||||.|:|||||||||||||:
Frog   105 FDRIVEKGFYTEKDASQLIKQILDAVKYLHDMGIVHRDLKPENLLYYSIDEDSKIMISDFGLSKI 169

  Fly   196 EDSG-IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKG 259
            |.|| :|:|||||||||||||||||||.||||.||||||:||||||||||||||||.||.||||.
Frog   170 EGSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA 234

  Fly   260 DFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF 324
            ::||||||||:||:|||.||::||.....||.||.|||.|.||:|:.|..:|||.:||||::|||
Frog   235 EYEFDSPYWDDISDSAKDFIQHLMEKDPNKRNTCDQALQHPWIAGDTALDKNIHESVSEQIRKNF 299

  Fly   325 AKSRWKQAYYAATVIRQMQRMALNSNSNA-------------------NFDSSNSSNQDSTTPTA 370
            ||||||||:.|..|:|.|:::.|.::...                   |..|.:.|.||..:|.:
Frog   300 AKSRWKQAFNATAVVRHMRKLQLGTSQEGPGQTTPTSPCHGNLLMPGDNHGSHSESCQDCCSPKS 364

  Fly   371 ATGAWTSNVLSSQQSVQSH 389
            :..  .|...|:|...||:
Frog   365 SEN--NSLAYSTQHCAQSN 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	182/274 (66%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	182/271 (67%)
camk1	NP_001016269.1	STKc_CaMKI_alpha	17..279	CDD:271069	184/286 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1766
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm47921
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100