DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and PHKG2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_000285.1	Gene:	PHKG2 / 5261	HGNCID:	8931	Length:	406	Species:	Homo sapiens

Alignment Length:	294	Identity:	110/294 - (37%)
Similarity:	163/294 - (55%)	Gaps:	32/294 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLE-------NEIRVLRRFS 86
            :||:...::|.|..|.||....: :.|..|||||::..|.:...|.||       .|..:||:.:
Human    22 QKYDPKDVIGRGVSSVVRRCVHR-ATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVA 85

  Fly    87 ANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQ 151
            .              ||:|:.|:::||..|.::||.:|:..|||||.:.||.:.:||:...::|.
Human    86 G--------------HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136

  Fly   152 ILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEV 215
            :||||.::|...:|||||||||:|.   ||:.:|.:||||.| .:|....:...||||||:|||:
Human   137 LLEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI 198

  Fly   216 L------AQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISES 274
            |      ....|||.||:|:.|||.:.||.|.|||:......:...|::|.::|.||.||:.|.:
Human   199 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSST 263

  Fly   275 AKHFIKNLMCVTVEKRYTCKQALGHAWISGNEAS 308
            .|..|..|:.|..|.|.|.:|||.|.:....|.|
Human   264 VKDLISRLLQVDPEARLTAEQALQHPFFERCEGS 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	108/285 (38%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	107/284 (38%)
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	108/286 (38%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920