DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Camk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_598687.1	Gene:	Camk1 / 52163	MGIID:	1098535	Length:	374	Species:	Mus musculus

Alignment Length:	371	Identity:	217/371 - (58%)
Similarity:	273/371 - (73%)	Gaps:	30/371 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDK 65
            ||  |..:..:..:|:|::::         |:...:|||||||||.|||.|.:. :..|:|.|.|
Mouse     1 MP--GAVEGPRWKQAEDIRDI---------YDFRDVLGTGAFSEVILAEDKRTQ-KLVAIKCIAK 53

  Fly    66 KALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGEL 130
            |||:|||.|:||||.||.               ::.|||||.|.:.||....:||:|:||:||||
Mouse    54 KALEGKEGSMENEIAVLH---------------KIKHPNIVALDDIYESGGHLYLIMQLVSGGEL 103

  Fly   131 FDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKM 195
            ||||||||.|||:|||.||.|:|:||.|:|:.|:||||||||||||||.|:||||||||||||||
Mouse   104 FDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM 168

  Fly   196 EDSG-IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKG 259
            ||.| :::|||||||||||||||||||.||||.||||||:||||||||||||||||.||.||||.
Mouse   169 EDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA 233

  Fly   260 DFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF 324
            ::||||||||:||:|||.||::||....|||:||:|||.|.||:|:.|..:|||.:||||:||||
Mouse   234 EYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNF 298

  Fly   325 AKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTA 370
            |||:||||:.|..|:|.|:::.|.::...  .....|:.:..||||
Mouse   299 AKSKWKQAFNATAVVRHMRKLQLGTSQEG--QGQTGSHGELLTPTA 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	180/274 (66%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	180/271 (66%)
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	182/286 (64%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316		24/39 (62%)
		Calmodulin-binding. /evidence=ECO:0000250	296..317		13/20 (65%)
		Nuclear export signal. /evidence=ECO:0000250	315..321		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1246
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm42812
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860