DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKI and mylkb

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_009300538.1	Gene:	mylkb / 492576	ZFINID:	ZDB-GENE-041111-150	Length:	966	Species:	Danio rerio

Alignment Length:	399	Identity:	129/399 - (32%)
Similarity:	210/399 - (52%)	Gaps:	43/399 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEV-RLAESKDSPGEHFAVKIIDKKALKGK 71
            |..|:.:.:|: .:.|..|:::.|::...||||.|.:| :|.|.  |..:.:|.|.|  ||...|
Zfish   505 DEEKEPEYRDV-VIKKDCSVKDFYDIEDRLGTGKFGQVFKLVEK--SSKKVWAGKFI--KAFSQK 564

  Fly    72 E-ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIV 135
            | |::..||.::               ..|.||.:||.::.:|.||.:.:|||:::|||||:|||
Zfish   565 EKENVRQEIGIM---------------NSLHHPKLVQCMDAFEGKSDMVMVMEMISGGELFERIV 614

  Fly   136 EKG-SYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDS 198
            ::. ..||::....:.||::.|.::|:||:||.||||||::..: ...|||.:.||||: ::|||
Zfish   615 DEDFELTEREVIKYMLQIIDGVQFIHKQGIVHLDLKPENIMCIN-KTGSKIKLIDFGLARRLEDS 678

  Fly   199 GIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEF 263
            |.:....|||.:|||||:..:......|:||||||.|||:.|..||..:||....|.:....::|
Zfish   679 GSLKVLFGTPEFVAPEVINYEAISYPTDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDF 743

  Fly   264 DSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHG--TVSEQLKKNFAK 326
            :...:||||:.||.||..|:...:..|.||.|...|:|:   :..::|:..  ...|::||...:
Zfish   744 EDEAFDEISDQAKDFISRLLKKDMRARLTCAQCFEHSWL---KQDTKNMEAKQLSKERMKKYILR 805

  Fly   327 SRWKQAYYAATVIRQMQRMALNSNSNANFDSS----------NSSNQDSTTPTAATGAWTSNVLS 381
            .||::...|...|.:...|.:.........|.          .|...::.||.|.:.|   :|:.
Zfish   806 RRWQKTGNAVRAISRFSSMGMLGGIGPKKSSPTEEEPPAPFLESVEDENHTPAAPSFA---SVIQ 867

  Fly   382 SQQSVQSHA 390
            ..:.|:..|
Zfish   868 DVEVVEGSA 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	105/277 (38%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	105/274 (38%)
mylkb	XP_009300538.1	I-set	166..255	CDD:254352
		IGc2	180..245	CDD:197706
		Ig	296..394	CDD:299845
		I-set	296..386	CDD:254352
		FN3	390..475	CDD:238020
		PKc_like	524..782	CDD:304357	105/277 (38%)
		Pkinase	527..782	CDD:278497	105/274 (38%)
		I-set	860..950	CDD:254352	4/20 (20%)
		IGc2	873..940	CDD:197706	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920