DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and camk2d1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_009301756.1	Gene:	camk2d1 / 445208	ZFINID:	ZDB-GENE-040801-121	Length:	591	Species:	Danio rerio

Alignment Length:	397	Identity:	152/397 - (38%)
Similarity:	222/397 - (55%)	Gaps:	46/397 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            ::|.|:..||.||||.||.. .|.|.|:.:|.|||:.|.|..:: :.||.|.|:.|
Zfish    11 DEYQLYEELGKGAFSVVRRC-MKISTGQEYAAKIINTKKLSARDHQKLEREARICR--------- 65

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|.|||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|:||||||.
Zfish    66 ------LLKHANIVRLHDSISEEGVHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            :.|:.|||||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.::
Zfish   125 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLRKE 188

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            ||||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||..|..::.
Zfish   189 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 253

  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIH--GTVSEQLKKNFAKSRWKQA--------------- 332
            :...||.|..:||.|.||......:..:|  .|| |.|||..|:.:.|.|
Zfish   254 INPAKRITAAEALKHPWICQRSTVASMMHRQETV-ECLKKFNARRKLKGAILTTMLATRNFSSKN 317

  Fly   333 -YYAATVIRQMQRMALNSNSNANFDSSNSSN---QDSTTPTAATGAWTSNVLSSQQSVQSHAQEM 393
             |.....:::.|...:::.::.|.:||.|:|   :|........ ::|.:.:.:::  |||:|:.
Zfish   318 PYKKPDGVKEPQTTVIHNPTDGNKESSESTNTTIEDEDIKVYRL-SYTPHRMFTRE--QSHSQQS 379

  Fly   394 NKSGGST 400
            ..|..|:
Zfish   380 CSSAASS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	125/275 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	125/274 (46%)
camk2d1	XP_009301756.1	STKc_CaMKII	11..302	CDD:270988	136/308 (44%)
		S_TKc	13..271	CDD:214567	125/274 (46%)
		CaMKII_AD	459..586	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920