DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKI and Unc-89

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster

Alignment Length:	285	Identity:	91/285 - (31%)
Similarity:	150/285 - (52%)	Gaps:	27/285 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEE---SLENEIRVLR 83
            :||:..::||::...||.|.......|..:.| |:::|.||     :.|:.|   .:.||:.::.
  Fly  3177 SKQLRYQDKYDIGDELGRGTQGITYHAVERSS-GDNYAAKI-----MYGRPELRPFMLNELEMMN 3235

  Fly    84 RFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELF-DRIVEKGSYTEKDASH 147
            .|:               |.|:::..:.|:....|.|:|||..||||. |.::.:..|||:|.:|
  Fly  3236 TFN---------------HKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDIAH 3285

  Fly   148 LIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYV 211
            .|||.|..:::|||.||.|..|..::||......|. |.:|||||| |:....:.....|.|.:|
  Fly  3286 YIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDI-IKVSDFGLSRKINRHNLSTLDYGMPEFV 3349

  Fly   212 APEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAK 276
            :|||:.::....:.|:|::|:|:|:||.|:.||...:|.....:|.:|.::|....|..||:..:
  Fly  3350 SPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDRETLTKIREGRWDFKDEIWTHISDDGR 3414

  Fly   277 HFIKNLMCVTVEKRYTCKQALGHAW 301
            .||..|:..:.|:|...|.||.|.|
  Fly  3415 DFISRLLLYSPEERMDVKTALKHPW 3439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	88/278 (32%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	88/276 (32%)
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254
		I-set	1123..1212	CDD:254352
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011	89/280 (32%)
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810