DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Dclk2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001009691.3	Gene:	Dclk2 / 310698	RGDID:	1308384	Length:	767	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	145/358 - (40%)
Similarity:	210/358 - (58%)	Gaps:	28/358 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NKQVSIEEKYNLHGLLGTGAFSEVRLAESKD-SPGEHFAVKIIDKKALKGKEESLENEIRVLRRF 85
            ::..::.|||.:..::|.|.|:.|:  |..| |.|:.||:|||||....|||..:|||:.:||
  Rat   400 SESFTLLEKYRIGKVIGDGNFAVVK--ECMDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR-- 460

  Fly    86 SANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIR 150
                         |:.||||:.|:|..|..::::||||||.||:|||.|.....|||:|.|.::.
  Rat   461 -------------RVKHPNIIMLVEEMETTTELFLVMELVKGGDLFDAITSSTKYTERDGSAMVY 512

  Fly   151 QILEAVDYMHEQGVVHRDLKPENLLYYS-PDDDSKIMISDFGLSKMEDSGIMATACGTPGYVAPE 214
            .:..|:.|:|...:||||:||||||... ||....:.:.||||:.:.: |.:.|.||||.|||||
  Rat   513 NLASALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYTVCGTPTYVAPE 576

  Fly   215 VLAQKPYGKAVDVWSIGVISYILLCGYPPFYDEND--ANLFAQILKGDFEFDSPYWDEISESAKH 277
            ::|:..||..||||:.|||:||||||:|||..||:  .:||.|||.|..||.:||||.|::|||.
  Rat   577 IIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKE 641

  Fly   278 FIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQM 342
            .|..::.|.||.|.|..:.|.|.|:|.:.:...|:...|:.:||::|..:..|| ....|.:..:
  Rat   642 LISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQ-NSTTTGVSVI 705

  Fly   343 QRMALNSN-----SNANFDSSNSSNQDSTTPTA 370
            ...||:..     |....|||.||.:.::...|
  Rat   706 MNTALDKEGQVFCSKHCRDSSKSSREQTSAREA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	126/277 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	124/274 (45%)
Dclk2	NP_001009691.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..391
		STKc_DCKL2	407..665	CDD:271086	126/275 (46%)
		S_TKc	409..666	CDD:214567	124/274 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..767		6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920