DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CaMKI and Dapk1

DIOPT Version :9

Sequence 1:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster
Sequence 2:XP_008769663.1 Gene:Dapk1 / 306722 RGDID:1311629 Length:1442 Species:Rattus norvegicus


Alignment Length:392 Identity:128/392 - (32%)
Similarity:203/392 - (51%) Gaps:34/392 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 KQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKG-----KEESLENEIRVL 82
            :|.::::.|:....||:|.|:.|:....| |.|..:|.|.|.|:..|.     ..|.:|.|:.:|
  Rat     5 RQENVDDYYDTGEELGSGQFAVVKKCREK-STGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68

  Fly    83 RRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASH 147
            :               .:.|||::.|.|.||:|:.|.|::|||.||||||.:.||.|.||::|:.
  Rat    69 K---------------EIRHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATE 118

  Fly   148 LIRQILEAVDYMHEQGVVHRDLKPENLLYYSPD-DDSKIMISDFGLS-KMEDSGIMATACGTPGY 210
            .::|||..|.|:|...:.|.||||||::....: ...:|.|.||||: |::.........|||.:
  Rat   119 FLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEF 183

  Fly   211 VAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESA 275
            ||||::..:|.|...|:||||||:||||.|..||..:......|.:...:::|:..::...|..|
  Rat   184 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLA 248

  Fly   276 KHFIKNLMCVTVEKRYTCKQALGHAWI---SGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAAT 337
            |.||:.|:....:||.|.:.:|.|.||   ...:|.||.......|:.||..|:.:|||:....:
  Rat   249 KDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLIS 313

  Fly   338 VIRQMQRMALNSNSNANFDSSNSS--NQDSTTPTAATGAWTSNVLSSQQ----SVQSH-AQEMNK 395
            :.:::.|..| |.||.:...|:.:  .:||....|...|...:.:...|    |:.|: ..:.||
  Rat   314 LCQRLSRSFL-SRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSSYDVNQPNK 377

  Fly   396 SG 397
            .|
  Rat   378 HG 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 99/280 (35%)
S_TKc 31..302 CDD:214567 99/277 (36%)
Dapk1XP_008769663.1 STKc_DAPK1 7..275 CDD:271096 99/283 (35%)
S_TKc 13..275 CDD:214567 99/277 (36%)
Ank_2 <337..409 CDD:289560 10/43 (23%)
ANK 373..497 CDD:238125 3/7 (43%)
ANK repeat 378..409 CDD:293786 1/2 (50%)
Ank_2 383..475 CDD:289560
ANK repeat 412..442 CDD:293786
ANK 439..564 CDD:238125
ANK repeat 444..475 CDD:293786
Ank_2 449..541 CDD:289560
ANK repeat 477..508 CDD:293786
ANK 505..629 CDD:238125
ANK repeat 510..541 CDD:293786
ANK repeat 543..574 CDD:293786
Ank_2 548..638 CDD:289560
ANK repeat 576..607 CDD:293786
ANK repeat 609..638 CDD:293786
Death_DAPK1 1308..1393 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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