DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and cmk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_593464.1	Gene:	cmk1 / 2542442	PomBaseID:	SPACUNK12.02c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	343	Identity:	140/343 - (40%)
Similarity:	202/343 - (58%)	Gaps:	28/343 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGK 71
            ||...||.. |.|:|     :..||.:..:||.|.::.||.|...:: .:.:|.||::||.::.|
pombe    13 KDGAPKATV-DQKQL-----LPCKYRVGRVLGGGTYATVREAVHIET-NKMYAAKIMNKKMMEKK 70

  Fly    72 EESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVE 136
            ::.::|||.:|:|.|             ..||||:.|::.:|..:.:||:.||.|||||||||..
pombe    71 QDFVKNEIAILKRVS-------------YEHPNILHLVDFFETVNNLYLITELATGGELFDRICA 122

  Fly   137 KGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKM-EDSG- 199
            |||:.|.||:.|:|....||.|:|:.|:||||||||||||.|.|.:|.::|:|||||.. |||.
pombe   123 KGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQY 187

  Fly   200 -IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEF 263
             ::.||||||.|:||||..:..|||.||:|:||||:|.||.||.||...:...:...||..::.|
pombe   188 YMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTF 252

  Fly   264 DSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF-AKS 327
            :.|.|..|||:||.|||..:.....||.|...||.|.::|....::.|:...|.|    || |:.
pombe   253 NDPCWSGISETAKDFIKKCLENDPSKRLTAADALKHPFLSEKRPATSNLLPNVRE----NFNARK 313

  Fly   328 RWKQAYYAATVIRQMQRM 345
            .::.||.|.......:::
pombe   314 TFRTAYNAVRAFNTWKKL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	123/276 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	122/273 (45%)
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	123/273 (45%)
cmk1	NP_593464.1	S_TKc	31..291	CDD:214567	122/273 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	203	1.000	Domainoid score	I636
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I830
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		oto100794
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
TreeFam	0	0.000	Not matched by this tool.
	10	9.890