DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and srk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_588136.1	Gene:	srk1 / 2539027	PomBaseID:	SPCC1322.08	Length:	580	Species:	Schizosaccharomyces pombe

Alignment Length:	494	Identity:	147/494 - (29%)
Similarity:	219/494 - (44%)	Gaps:	127/494 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKDSGKKAKAKDLKELNKQVSIE-------------EKYNLHGLLGTGAFSEVRLAESKDSPGEH 57
            |:.:.:|...|.::.|..:..:|             |:|.|...:|.||||.|..| ..:..||.
pombe    86 KQPTNEKEYDKAIEALVAKAIVEEHSGQQFPVYKGLEQYTLLQKMGDGAFSNVYKA-IHNRTGEK 149

  Fly    58 FAVKII----------DKKALKGKE-ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLET 111
            .|:|::          |.:..:|.| .::..|::::|               |:.||||:||||.
pombe   150 VAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMR---------------RVKHPNIIQLLEF 199

  Fly   112 YEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQ-GVVHRDLKPENLL 175
            .:.....|||:||..|||||.:||....::|..:.|:|.|:..|:.|:||. ||||||:||||||
pombe   200 IQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQVAHAIRYLHEDCGVVHRDIKPENLL 264

  Fly   176 Y------------YSPDDD------------------SKIMISDFGLSKMEDSGIMATACGTPGY 210
            :            |...||                  .:|.::||||||:.......|.|||.||
pombe   265 FDSIDFVPSRVRKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLSKVVWDSHTQTPCGTMGY 329

  Fly   211 VAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESA 275
            .|||::..:.|.|.||:|::|.:.|.:|||:||||||:.:.|..::.:|::.|.||:||:||:||
pombe   330 TAPEIVRDERYSKGVDMWALGCVLYTILCGFPPFYDESISLLTKKVSRGEYSFLSPWWDDISKSA 394

  Fly   276 KHFIKNLMCVTVEKRYTCKQALGHAWISG------------NEASSRN----------------- 311
            |..|.:|:.|..|.||...|.|.|.||||            |.|...|
pombe   395 KDLISHLLTVDPESRYDIHQFLAHPWISGSREPTFPATDAPNTAQRENPFTYDFLEPEDVAAAGS 459

  Fly   312 -------------------IHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNSNSNANFDS 357
                               .|....|:::|.  ..|..|.     ::..|..|......|.::|.
pombe   460 AARTPGVNSLREVFNISYAAHRMEQEKIRKR--GQRGNQG-----IMNFMGDMDDLMEENDDYDD 517

  Fly   358 SNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNKS 396
            ...|.:.|......:|. ....|:|:|..||..|...:|
pombe   518 GTKSVEHSMKRVNLSGE-NDPSLASRQPAQSQQQSSQRS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	117/328 (36%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	115/312 (37%)
srk1	NP_588136.1	STKc_RCK1-like	122..421	CDD:270998	116/314 (37%)
srk1	NP_588136.1	S_TKc	124..421	CDD:214567	115/312 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810