DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Camk2d

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_036651.1	Gene:	Camk2d / 24246	RGDID:	2263	Length:	533	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	147/396 - (37%)
Similarity:	204/396 - (51%)	Gaps:	50/396 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            ::|.|...||.||||.||.. .|...|:.:|.|||:.|.|..:: :.||.|.|:.|
  Rat    12 DEYQLFEELGKGAFSVVRRC-MKIPTGQEYAAKIINTKKLSARDHQKLEREARICR--------- 66

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|||||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|:||||:|:
  Rat    67 ------LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            :.|..|:|||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.:.
  Rat   126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLRKD 189

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            ||||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||..|..::.
  Rat   190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 254

  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNS 349
            :...||.|..:||.|.||......:..:|...:....|.|...|..:.....|::......|..|
  Rat   255 INPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKS 319

  Fly   350 ----------NSNANFDSSNSSNQDSTTPTAATGAWT---------------SNVLSSQQSVQSH 389
                      |:.||..:|...|    .||.|....|               ||.....:.|::.
  Rat   320 LLKKPDGVKINNKANVVTSPKEN----IPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKAR 380

  Fly   390 AQEMNK 395
            .||:.|
  Rat   381 KQEIIK 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	123/275 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	123/274 (45%)
Camk2d	NP_036651.1	STKc_CaMKII	12..303	CDD:270988	129/307 (42%)
		S_TKc	14..272	CDD:214567	123/274 (45%)
		Autoinhibitory domain. /evidence=ECO:0000250	283..292		1/8 (13%)
		Calmodulin-binding. /evidence=ECO:0000250	291..301		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..375		8/41 (20%)
		CaMKII_AD	380..507	CDD:285524	3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920