DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Camkv

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_663596.1	Gene:	Camkv / 235604	MGIID:	2384296	Length:	512	Species:	Mus musculus

Alignment Length:	397	Identity:	155/397 - (39%)
Similarity:	245/397 - (61%)	Gaps:	36/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRV 81
            |.|..|:...:.::|:|..::.|..|.|:..|:.| :.|:....|...|:..:...::.:|||.:
Mouse    10 DKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDK-TTGKLHTCKKFQKRDGRKVRKAAKNEIGI 73

  Fly    82 LRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDAS 146
            |:               .:.||||:||::.:..:.:.::.:||.||.|:||.|:::|.|:|:|.|
Mouse    74 LK---------------MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTS 123

  Fly   147 HLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMATACGTPGYV 211
            :::||:||||.|:|...:|||:||.|||:||:...:|||:||||.|:|:| :|::...||||.|:
Mouse   124 NVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE-NGLIKEPCGTPEYL 187

  Fly   212 APEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDE--------NDANLFAQILKGDFEFDSPYW 268
            ||||:.::.||:.||.|:||||.||||.|.||||:|        :|.|||.:||.||:|||||||
Mouse   188 APEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252

  Fly   269 DEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAY 333
            |:||::||..:..||.|..::|.|.::|:.|.|||||.||.:||...|..|::||||:::||:|.
Mouse   253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAV 317

  Fly   334 YAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNKSGG 398
            ...|:   |:|:.....|..   ::..|..|:.||.||.||     :::..:..:.....:.||.
Mouse   318 RVTTL---MKRLRAPEQSGT---AATQSASDAATPGAAGGA-----IAAAAAAAAAGGAASASGA 371

  Fly   399 STNAASQ 405
            |..||::
Mouse   372 SATAATE 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	117/281 (42%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	117/278 (42%)
Camkv	NP_663596.1	STKc_CaMK_like	22..286	CDD:270990	117/280 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..347		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..512
		DUF5585	397..>511	CDD:375359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920