DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Mylk2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001074513.2	Gene:	Mylk2 / 228785	MGIID:	2139434	Length:	613	Species:	Mus musculus

Alignment Length:	333	Identity:	104/333 - (31%)
Similarity:	168/333 - (50%)	Gaps:	25/333 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANH 89
            |:.|...|....||.|.|..|.....: :.|...|.|:|.|:..|.||..| .||.|:
Mouse   296 VNSEFSMNSKEALGGGKFGAVCTCTER-ATGLKLAAKVIKKQTPKDKEMVL-LEIEVM------- 351

  Fly    90 FDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSY-TEKDASHLIRQIL 153
                    .:|.|.|::||....|...::.|.||.:.|||||:|||::..: ||.|....:|||.
Mouse   352 --------NQLNHRNLIQLYAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQIC 408

  Fly   154 EAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEVLA 217
            :.:.:||:..|:|.||||||:|..: .....:.|.||||: :...:..:....|||.:::|||:.
Mouse   409 DGILFMHKMRVLHLDLKPENILCVN-TTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVN 472

  Fly   218 QKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNL 282
            ........|:||:|||:|:||.|..||..::|......:|..::.||...::.:|:.||.|:.||
Mouse   473 YDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNL 537

  Fly   283 MCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQ--LKKNFAKSRWKQAYYAATVIRQMQRM 345
            :......|.:.:|.|.|.|::.....::..:..:..|  |||...|.|||:.:.|.:...:.:::
Mouse   538 LTKDQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKI 602

  Fly   346 ALNSNSNA 353
               |:|.|
Mouse   603 ---SSSGA 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	90/275 (33%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	89/272 (33%)
Mylk2	NP_001074513.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..240
		STKc_MLCK2	298..557	CDD:271092	90/276 (33%)
		S_TKc	308..557	CDD:214567	88/266 (33%)
		Calmodulin-binding. /evidence=ECO:0000250	591..603		1/14 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900