DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Camk1d

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_796317.2	Gene:	Camk1d / 227541	MGIID:	2442190	Length:	385	Species:	Mus musculus

Alignment Length:	388	Identity:	229/388 - (59%)
Similarity:	280/388 - (72%)	Gaps:	36/388 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALK 69
            |:..|..|.:|:|:|::         :.....|||||||||.|||.| :.|:.||||.|.|||||
Mouse     6 GESSSSWKKQAEDIKKI---------FEFKETLGTGAFSEVVLAEEK-ATGKLFAVKCIPKKALK 60

  Fly    70 GKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRI 134
            |||.|:||||.|||               ::.|.|||.|.:.||..:.:||||:||:||||||||
Mouse    61 GKESSIENEIAVLR---------------KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRI 110

  Fly   135 VEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSG 199
            ||||.|||||||.||||:|:||.|:|..|:||||||||||||||.|::||||||||||||||..|
Mouse   111 VEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG 175

  Fly   200 -IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEF 263
             :|:|||||||||||||||||||.||||.||||||:|||||||||||||||:.||.||||.::||
Mouse   176 DVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240

  Fly   264 DSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSR 328
            ||||||:||:|||.||:|||.....|||||:||..|.||:|:.|.|:|||.:||.|::||||||:
Mouse   241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSK 305

  Fly   329 WKQAYYAATVIRQMQRMALNS---NSNANFDS--SNSSNQDSTTPTAATGAWTSNVLSSQQSV 386
            |:||:.|..|:|.|:|:.|.|   :|||:..|  |.:|.:|...|:.     ..:.|||...|
Mouse   306 WRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPST-----LCSFLSSSSGV 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	184/274 (67%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	184/271 (68%)
Camk1d	NP_796317.2	STKc_CaMKI_delta	12..312	CDD:271070	208/324 (64%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		22/39 (56%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320		12/20 (60%)
		Nuclear export signal. /evidence=ECO:0000250	318..324		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..385		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831943
Domainoid	1	1.000	319	1.000	Domainoid score	I1246
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1735
Isobase	1	0.950	-	0	Normalized mean entropy	S755
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm42812
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740