DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Trio

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001074771.1	Gene:	Trio / 223435	MGIID:	1927230	Length:	3103	Species:	Mus musculus

Alignment Length:	353	Identity:	102/353 - (28%)
Similarity:	160/353 - (45%)	Gaps:	54/353 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DSGKKAKAKDLKEL---NKQVSIEEKYNLHGL------LGTGAFSEVRLAESKDSPGEHFAVKII 63
            |.|..:.:..|:.|   :..:.:..|.|....      ||.|.|:.|:..:.|.:. ...|.|.:
Mouse  2768 DMGSASSSASLRVLGPGSDGIVVTWKDNFDAFYSEVAELGRGRFAVVKKCDQKGTK-RAVATKFV 2831

  Fly    64 DKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGG 128
            :||.:  |.:.:.:|:.:|:               .|.||.:|.||:|:|..:...||:|:...|
Mouse  2832 NKKLM--KRDQVTHELGILQ---------------NLQHPLLVSLLDTFETPTSYVLVLEMADQG 2879

  Fly   129 ELFDRIVEKGSYTE-KDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFG- 191
            .|.|.:|..||.|| |..:|| .::||||.|:|...:.|.||||||:|.........|.::|||
Mouse  2880 RLLDCVVRWGSLTEGKVRAHL-GEVLEAVRYLHNCRIAHLDLKPENILVDQSLAKPTIKLADFGD 2943

  Fly   192 LSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQI 256
            ..::..:..:....|.|.:.|||::...|.....|.||:||::|:||.|..||.|::.......|
Mouse  2944 AVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTADTWSVGVLTYVLLSGVSPFLDDSVEETCLNI 3008

  Fly   257 LKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGT------ 315
            .:.||.|...|:..:|:.||.|:..|:.....||.:...||...|:.....|.:   ||
Mouse  3009 CRLDFSFPEDYFQGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGSGK---GTGVLDTS 3070

  Fly   316 ----VSEQLK-----------KNFAKSR 328
                ..|:.|           |||.:||
Mouse  3071 RLTSFIERRKHQNDVRPIRSIKNFLQSR 3098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	87/281 (31%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	86/278 (31%)
Trio	NP_001074771.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SEC14	69..204	CDD:214706
		Spectrin 1	218..338
		SPEC	220..445	CDD:238103
		Spectrin 2	340..446
		SPEC	341..566	CDD:238103
		Spectrin 3	566..672
		SPEC	567..783	CDD:238103
		Spectrin 4	673..784
		SPEC	787..1014	CDD:238103
		Spectrin 5	907..1012
		SPEC	908..1137	CDD:238103
		Spectrin 6	1138..1244
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1651
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1957
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		SH3_Kalirin_2	2559..2617	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2643..2666
		I-set	2689..2780	CDD:254352	3/11 (27%)
		Ig	2703..2780	CDD:299845	3/11 (27%)
		STKc_Trio_C	2792..3054	CDD:271015	87/280 (31%)
		S_TKc	2800..3054	CDD:214567	85/272 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900