DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and cmk-1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_500139.1	Gene:	cmk-1 / 176989	WormBaseID:	WBGene00000553	Length:	348	Species:	Caenorhabditis elegans

Alignment Length:	372	Identity:	244/372 - (65%)
Similarity:	285/372 - (76%)	Gaps:	28/372 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLFGKKD-SGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIID 64
            ||||.::| ||....|          :|.|||:...:|||||||:|.|||||...|:.:|||.||
Worm     1 MPLFKRRDGSGPAPNA----------TIREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCID 55

  Fly    65 KKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGE 129
            |||||||||||||||:|||               :|.|.|||||.:||::|..||||||||||||
Worm    56 KKALKGKEESLENEIKVLR---------------KLRHNNIVQLFDTYDEKQFVYLVMELVTGGE 105

  Fly   130 LFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK 194
            ||||||.||||||:|||:||||:||||.:||:.|||||||||||||||:.|:|||||||||||||
Worm   106 LFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSK 170

  Fly   195 MEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKG 259
            .||||:||||||||||||||||.||||||||||||||||:|||||||||||||:||||||||:||
Worm   171 TEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKG 235

  Fly   260 DFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF 324
            ::|||:||||:||:|||.||.:|||...|.|:||:.||.|.|||||.|.:.:|||||:..|||:.
Worm   236 EYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNTAYTHDIHGTVAVHLKKSL 300

  Fly   325 AKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAA 371
            ||..||:||.||..|||:|.:.|:||||..  ...:|.|....||.|
Worm   301 AKRNWKKAYNAAAAIRQLQMLRLSSNSNRL--QKQASQQQPEPPTPA 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	200/273 (73%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	197/270 (73%)
cmk-1	NP_500139.1	STKc_CaMKI	18..277	CDD:270985	200/273 (73%)
cmk-1	NP_500139.1	S_TKc	22..278	CDD:214567	197/270 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I562
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137628
Inparanoid	1	1.050	474	1.000	Inparanoid score	I825
Isobase	1	0.950	-	0	Normalized mean entropy	S755
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		oto20413
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820