Protein Alignment CaMKI and DCLK2

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001035351.4
• Gene: DCLK2 / 166614
• HGNCID: 19002
• Length: 783
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 148/367 - (40%)
• Similarity: 210/367 - (57%)
• Gaps: 40/367 - (10%)

  Fly    20 ELNKQVSIE--------------EKYNLHGLLGTGAFSEVRLAESKD-SPGEHFAVKIIDKKALK 69
            ||::.:|.|              |||.:..::|.|.|:.|:  |..| |.|:.||:|||||....
Human   386 ELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVK--ECIDRSTGKEFALKIIDKAKCC 448

  Fly    70 GKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRI 134
            |||..:|||:.:||               |:.||||:.|:|..|..::::||||||.||:|||.|
Human   449 GKEHLIENEVSILR---------------RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI 498

  Fly   135 VEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYS-PDDDSKIMISDFGLSKMEDS 198
            .....|||:|.|.::..:..|:.|:|...:||||:||||||... ||....:.:.||||:.:.:
Human   499 TSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE- 562

  Fly   199 GIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDEND--ANLFAQILKGDF 261
            |.:.|.||||.|||||::|:..||..||:|:.|||:||||||:|||..||:  .:||.|||.|..
Human   563 GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKL 627

  Fly   262 EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAK 326
            ||.:||||.|::|||..|..::.|.||.|.|..|.|.|.|:|.:.:...|:...|:.:||::|..
Human   628 EFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNN 692

  Fly   327 SRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTP 368
            :..|| ....|.:..:...||:..... |.|.:.  |||..|
Human   693 ALPKQ-NSTTTGVSVIMNTALDKEGQI-FCSKHC--QDSGRP 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	127/291 (44%)
DCLK2	NP_001035351.4	DCX1_DCLK2	70..154	CDD:340661
		DCX2	193..276	CDD:340589
		STKc_DCKL2	409..667	CDD:271086	126/275 (46%)