DRSC/TRiP Functional Genomics Resources

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Protein Alignment CaMKI and DCLK2

DIOPT Version :9

Sequence 1:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster
Sequence 2:NP_001035351.4 Gene:DCLK2 / 166614 HGNCID:19002 Length:783 Species:Homo sapiens


Alignment Length:367 Identity:148/367 - (40%)
Similarity:210/367 - (57%) Gaps:40/367 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ELNKQVSIE--------------EKYNLHGLLGTGAFSEVRLAESKD-SPGEHFAVKIIDKKALK 69
            ||::.:|.|              |||.:..::|.|.|:.|:  |..| |.|:.||:|||||....
Human   386 ELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVK--ECIDRSTGKEFALKIIDKAKCC 448

  Fly    70 GKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRI 134
            |||..:|||:.:||               |:.||||:.|:|..|..::::||||||.||:|||.|
Human   449 GKEHLIENEVSILR---------------RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAI 498

  Fly   135 VEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYS-PDDDSKIMISDFGLSKMEDS 198
            .....|||:|.|.::..:..|:.|:|...:||||:||||||... ||....:.:.||||:.:.: 
Human   499 TSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE- 562

  Fly   199 GIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDEND--ANLFAQILKGDF 261
            |.:.|.||||.|||||::|:..||..||:|:.|||:||||||:|||..||:  .:||.|||.|..
Human   563 GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKL 627

  Fly   262 EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAK 326
            ||.:||||.|::|||..|..::.|.||.|.|..|.|.|.|:|.:.:...|:...|:.:||::|..
Human   628 EFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNN 692

  Fly   327 SRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTP 368
            :..|| ....|.:..:...||:..... |.|.:.  |||..|
Human   693 ALPKQ-NSTTTGVSVIMNTALDKEGQI-FCSKHC--QDSGRP 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 127/291 (44%)
S_TKc 31..302 CDD:214567 124/274 (45%)
DCLK2NP_001035351.4 DCX 67..157 CDD:214711
DCX 192..280 CDD:214711
STKc_DCKL2 409..667 CDD:271086 126/275 (46%)
S_TKc 411..668 CDD:214567 124/274 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D330091at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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