Protein Alignment CaMKI and PNCK

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001034671.3
• Gene: PNCK / 139728
• HGNCID: 13415
• Length: 426
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 195/332 - (58%)
• Similarity: 250/332 - (75%)
• Gaps: 19/332 - (5%)

  Fly    16 KDLKELNKQV-SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHF-AVKIIDKKALKGKEESLENE 78
            :|:..|.|.. .|...|.:...||:||||||.||:.:.|  .|. |:|.|.||||:|||..:|||
Human    82 QDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGS--AHLVALKCIPKKALRGKEALVENE 144

  Fly    79 IRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEK 143
            |.||||.|               |||||.|.:.:|..|.:||.|||||||||||||:|:||||||
Human   145 IAVLRRIS---------------HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEK 194

  Fly   144 DASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMATACGTP 208
            |||||:.|:|.||.|:|..|:||||||||||||.:|.:|||||:|||||||::...::.||||||
Human   195 DASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTP 259

  Fly   209 GYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISE 273
            ||||||:|.|||||||||||::|||||||||||||||||:|..||:|||:..:|||||:||:|||
Human   260 GYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324

  Fly   274 SAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATV 338
            |||.||::|:....:||:||:|||.|.||||:.|..|:|.|:||||::||||::.||:|:.|.:.
Human   325 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSF 389

  Fly   339 IRQMQRM 345
            :|.::::
Human   390 LRHIRKL 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	171/274 (62%)
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	181/292 (62%)