DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and PNCK

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001034671.3	Gene:	PNCK / 139728	HGNCID:	13415	Length:	426	Species:	Homo sapiens

Alignment Length:	332	Identity:	195/332 - (58%)
Similarity:	250/332 - (75%)	Gaps:	19/332 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KDLKELNKQV-SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHF-AVKIIDKKALKGKEESLENE 78
            :|:..|.|.. .|...|.:...||:||||||.||:.:.|  .|. |:|.|.||||:|||..:|||
Human    82 QDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGS--AHLVALKCIPKKALRGKEALVENE 144

  Fly    79 IRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEK 143
            |.||||.|               |||||.|.:.:|..|.:||.|||||||||||||:|:||||||
Human   145 IAVLRRIS---------------HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEK 194

  Fly   144 DASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMATACGTP 208
            |||||:.|:|.||.|:|..|:||||||||||||.:|.:|||||:|||||||::...::.||||||
Human   195 DASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTP 259

  Fly   209 GYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISE 273
            ||||||:|.|||||||||||::|||||||||||||||||:|..||:|||:..:|||||:||:|||
Human   260 GYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324

  Fly   274 SAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATV 338
            |||.||::|:....:||:||:|||.|.||||:.|..|:|.|:||||::||||::.||:|:.|.:.
Human   325 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSF 389

  Fly   339 IRQMQRM 345
            :|.::::
Human   390 LRHIRKL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	171/274 (62%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	170/271 (63%)
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	181/292 (62%)
PNCK	NP_001034671.3	S_TKc	98..353	CDD:214567	170/271 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1246
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1762
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm40739
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860