DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Dclk1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_064362.1	Gene:	Dclk1 / 13175	MGIID:	1330861	Length:	756	Species:	Mus musculus

Alignment Length:	388	Identity:	141/388 - (36%)
Similarity:	220/388 - (56%)	Gaps:	37/388 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKKDSGKKAKAKDLKELNKQV--SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKA 67
            |::.|.::...::..|...|:  :|.|:|.:...:|.|.|:.|:....: |....:|:|||.|..
Mouse   378 GRRHSLQRGWRREESEEGFQIPATITERYKVGRTIGDGNFAVVKECIER-STAREYALKIIKKSK 441

  Fly    68 LKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFD 132
            .:|||..::||:.:||               |:.|||||.|:|..:..:::|||||||.||:|||
Mouse   442 CRGKEHMIQNEVSILR---------------RVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFD 491

  Fly   133 RIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSK-IMISDFGLSKME 196
            .|.....|||:|||.::..:..|:.|:|...:||||:||||||.|...|.|| :.:.||||:.:.
Mouse   492 AITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV 556

  Fly   197 DSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDAN--LFAQILKG 259
            | |.:.|.||||.|||||::|:..||..||:|:.|||:||||||:|||....|..  ||.|||.|
Mouse   557 D-GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMG 620

  Fly   260 DFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF 324
            ..:|.|||||.:|:|||..|..::.|.|::|::..|.|.|.|::.:.........:|:.::||:|
Mouse   621 QVDFPSPYWDNVSDSAKELINMMLLVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHF 685

  Fly   325 ------AKSRWKQAYYAATVI---RQMQRMALNSNSNANFDSS------NSSNQDSTTPTAAT 372
                  :.:....:..|.|.:   ||:.|...|.:..:.:.:.      ||.::|.:..::.|
Mouse   686 NTGPKPSSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSET 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	122/276 (44%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	120/273 (44%)
Dclk1	NP_064362.1	DCX	52..142	CDD:214711
		DCX	181..269	CDD:214711
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..393		2/14 (14%)
		STKc_DCKL1	399..666	CDD:271085	123/283 (43%)
		S_TKc	406..663	CDD:214567	120/273 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..756		7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820