DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Camk2b

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_006514527.1	Gene:	Camk2b / 12323	MGIID:	88257	Length:	667	Species:	Mus musculus

Alignment Length:	383	Identity:	146/383 - (38%)
Similarity:	207/383 - (54%)	Gaps:	37/383 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92
            ::|.|:..:|.||||.||.. .|...|..:|.|||:.|.|..:: :.||.|.|:.|
Mouse    12 DEYQLYEDIGKGAFSVVRRC-VKLCTGHEYAAKIINTKKLSARDHQKLEREARICR--------- 66

  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157
                  .|.|.|||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|:||||||.
Mouse    67 ------LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 125

  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219
            :.|:.|||||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.::
Mouse   126 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVLRKE 189

  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284
            .|||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||:.|..::.
Mouse   190 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254

  Fly   285 VTVEKRYTCKQALGHAWISGNEASSRNIH--GTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMAL 347
            :...||.|..:||.|.|:......:..:|  .|| |.|||..|:.:.|.|.....:
Mouse   255 INPAKRITAHEALKHPWVCQRSTVASMMHRQETV-ECLKKFNARRKLKGAILTTML--------- 309

  Fly   348 NSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQS-VQSHAQEMNKSGGSTNAAS 404
               :..||.....:...:|..|||:|.....|..:.:| :...|..:.....||..:|
Mouse   310 ---ATRNFSVGRQTTAPATMSTAASGTTMGLVEQAAKSLLNKKADGVKPQTNSTKNSS 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	122/275 (44%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	122/274 (45%)
Camk2b	XP_006514527.1	STKc_CaMKII	12..303	CDD:270988	132/308 (43%)
Camk2b	XP_006514527.1	CaMKII_AD	535..662	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920