DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKI and Mylk2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_476557.2	Gene:	Mylk2 / 117558	RGDID:	620934	Length:	610	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	105/333 - (31%)
Similarity:	167/333 - (50%)	Gaps:	25/333 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANH 89
            |:.|...|....||.|.|..|.....: |.|...|.|:|.|:..|.||..| .||.|:
  Rat   293 VNSEFSMNSKEALGGGKFGAVCTCTER-STGLKLAAKVIKKQTPKDKEMVL-LEIEVM------- 348

  Fly    90 FDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKG-SYTEKDASHLIRQIL 153
                    .:|.|.|::||....|...::.|.||.:.|||||:|||::. ..||.|....:|||.
  Rat   349 --------NQLNHRNLIQLYSAIETSHEIILFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQIC 405

  Fly   154 EAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDSGIMATACGTPGYVAPEVLA 217
            :.:.:||:..|:|.||||||:|..: .....:.|.||||: :...:..:....|||.:::|||:.
  Rat   406 DGILFMHKMRVLHLDLKPENILCVN-TTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVN 469

  Fly   218 QKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNL 282
            ........|:||:|||:|:||.|..||..::|......:|..::.||...::.:|:.||.|:.||
  Rat   470 YDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNL 534

  Fly   283 MCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQ--LKKNFAKSRWKQAYYAATVIRQMQRM 345
            :......|.:.:|.|.|.|::.....::..:..:..|  |||...|.|||:.:.|.:...:.:::
  Rat   535 ITKDQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKI 599

  Fly   346 ALNSNSNA 353
               |:|.|
  Rat   600 ---SSSGA 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	91/275 (33%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	90/272 (33%)
Mylk2	NP_476557.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..240
		PKc_like	295..554	CDD:419665	91/276 (33%)
		Calmodulin-binding. /evidence=ECO:0000250	588..600		1/14 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900