DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Stk33

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_473444.1	Gene:	Stk33 / 117229	MGIID:	2152419	Length:	491	Species:	Mus musculus

Alignment Length:	397	Identity:	134/397 - (33%)
Similarity:	211/397 - (53%)	Gaps:	49/397 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDK-KALKGKEESLENEIRVLRRFSANHF 90
            |||.|....:||.|:|..|..|..|:: |..:|:|.::| ||.....:.||.|:.:|:
Mouse   107 IEEFYTFGRILGQGSFGMVFEAIDKET-GAKWAIKKVNKEKAGSSAMKLLEREVSILK------- 163

  Fly    91 DGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEA 155
                    .:.|.:|:.|.:.:|...|:||||||...|||...:.::|.::|.:...:|:.:..|
Mouse   164 --------TVNHQHIIHLEQVFESPQKMYLVMELCEDGELKAVMDQRGHFSENETRLIIQSLASA 220

  Fly   156 VDYMHEQGVVHRDLKPENLLYYSP--DDDSK----IMISDFGLSKME----DSGIMATACGTPGY 210
            :.|:|.:.:||||||.||::..|.  ||:::    |.::|||||..:    ..|:|.|.||||.|
Mouse   221 IAYLHNKDIVHRDLKLENIMVKSSFIDDNNEMNLNIKVTDFGLSVQKHGSRSEGMMQTTCGTPIY 285

  Fly   211 VAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESA 275
            :||||:....|.:..|:||||||.:|||||.|||...::..|:..|.||:..|::|.|:.:|:||
Mouse   286 MAPEVINAHDYSQQCDIWSIGVIMFILLCGEPPFLANSEEKLYELIKKGELRFENPVWESVSDSA 350

  Fly   276 KHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWK---QAYYAAT 337
            |:.:|.||.|....|.|.|:.|.:.|::||..||.. ...|.|.:|:      ||   ::.....
Mouse   351 KNTLKQLMKVDPAHRITAKELLDNQWLTGNTLSSAR-PTNVLEMMKE------WKNNPESDEETN 408

  Fly   338 VIRQMQRMALNSNSNANFDSSNSSNQDSTT---PTAATGAWTSNVLSSQQ--SVQSHAQEMNKSG 397
            ...:.::.|:.|      .|:|::.|.:..   |.|.:...||:..||.:  |.:|.| |..||.
Mouse   409 TDEETEQSAVYS------PSANTAKQPTNAAKKPAAESVGMTSSNSSSSKLLSAESKA-EPEKSS 466

  Fly   398 GSTNAAS 404
            .:...||
Mouse   467 ETVGHAS 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	105/284 (37%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	102/281 (36%)
Stk33	NP_473444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89
		PKc_like	109..377	CDD:419665	103/283 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..491		20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820