DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Chek2

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_446129.1	Gene:	Chek2 / 114212	RGDID:	621543	Length:	545	Species:	Rattus norvegicus

Alignment Length:	311	Identity:	116/311 - (37%)
Similarity:	168/311 - (54%)	Gaps:	44/311 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IEEKYNLHGLLGTGAFSEVRLA-ESKDSPGEHFAVKIIDKK--ALKGKEE-----SLENEIRVLR 83
            :.::|.:...||:||..||::| |.|..  :..|:|||.|:  ||....|     |:|.||.:|:
  Rat   219 LRDEYIMSKTLGSGACGEVKMAFERKTC--KKVAIKIISKRRFALGSSREADTAPSVETEIEILK 281

  Fly    84 RFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHL 148
                           :|.||.|:::.:.: |....|:|:||:.|||||||:|......|......
  Rat   282 ---------------KLNHPCIIKIKDVF-DVEDYYIVLELMEGGELFDRVVGNKRLKEATCKLY 330

  Fly   149 IRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK-MEDSGIMATACGTPGYVA 212
            ..|:|.||.|:||.|::||||||||:|..|.::|..|.|:|||.|| :.::.:|.|.||||.|:|
  Rat   331 FYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLA 395

  Fly   213 PEVLAQK---PYGKAVDVWSIGVISYILLCGYPPFYD-ENDANLFAQILKGDFEFDSPYWDEISE 273
            ||||...   .|.:|||.||:|||.:|.|.|||||.: :...:|..||..|.:......|.::||
  Rat   396 PEVLISNGTAGYSRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNLIPEVWTDVSE 460

  Fly   274 SAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNF 324
            .|...:|.|:.|..:.|.|.::||.|.|:.             .|.:||.|
  Rat   461 KALDLVKKLLVVDPKARLTTEEALSHPWLQ-------------DEHMKKKF 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	111/286 (39%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	111/283 (39%)
Chek2	NP_446129.1	FHA	96..204	CDD:238017
Chek2	NP_446129.1	STKc_Chk2	216..489	CDD:270986	111/287 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910