DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Mylk

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_647461.3	Gene:	Mylk / 107589	MGIID:	894806	Length:	1950	Species:	Mus musculus

Alignment Length:	385	Identity:	129/385 - (33%)
Similarity:	212/385 - (55%)	Gaps:	37/385 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DSGKKAKAKDLK--ELNKQVSIEEKYNLHGLLGTGAFSEV-RLAESKDSPGEHFAVKIIDKKALK 69
            |..:|....|.:  .:|.:..:.:.|::...||:|.|.:| ||.|.|  .|:.:|.|..  ||..
Mouse  1470 DDDEKEPEVDYRTVTVNTEQKVSDVYDIEERLGSGKFGQVFRLVEKK--TGKIWAGKFF--KAYS 1530

  Fly    70 GKE-ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDR 133
            .|| :::..||.::          .||:     ||.:||.::.:|:|:.:.:|:|:|:|||||:|
Mouse  1531 AKEKDNIRQEISIM----------NCLH-----HPKLVQCVDAFEEKANIVMVLEIVSGGELFER 1580

  Fly   134 IVEKG-SYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KME 196
            |:::. ..||::....:|||.|.|:|:|:||:||.||||||::..: ...::|.:.||||: ::|
Mouse  1581 IIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVN-KTGTRIKLIDFGLARRLE 1644

  Fly   197 DSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDF 261
            ::|.:....|||.:|||||:..:|.|.|.|:||||||.|||:.|..||..:||....|.:....:
Mouse  1645 NAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATW 1709

  Fly   262 EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAK 326
            :||...:||||:.||.||.||:...::.|..|.|.|.|.|:. .:..:........:::||..|:
Mouse  1710 DFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM-KDTKNMEAKKLSKDRMKKYMAR 1773

  Fly   327 SRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSV 386
            .:|::...|...|.::..||:.|..:....|:.|       ||:...|   ..|.|:..|
Mouse  1774 RKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGS-------PTSPINA---EKLESEDDV 1823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	107/277 (39%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	107/274 (39%)
Mylk	NP_647461.3	I-set	42..132	CDD:254352
		Ig	42..131	CDD:299845
		I-set	165..254	CDD:254352
		Ig	183..251	CDD:143165
		23ISL	255..409	CDD:293226
		I-set	411..501	CDD:254352
		Ig	428..498	CDD:143165
		I-set	511..597	CDD:254352
		IGc2	524..587	CDD:197706
		I-set	620..709	CDD:254352
		Ig	637..706	CDD:143165
		I-set	718..806	CDD:254352
		Ig	721..806	CDD:299845
		I-set	1129..1218	CDD:254352
		IGc2	1142..1208	CDD:197706
		Ig	1269..1366	CDD:299845
		I-set	1269..1358	CDD:254352
		FN3	1362..1453	CDD:238020
		STKc_MLCK1	1492..1750	CDD:271093	107/277 (39%)
		Pkinase	1495..1750	CDD:278497	107/274 (39%)
		I-set	1840..1930	CDD:254352
		IGc2	1853..1920	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010