DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and mylk

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_031749515.1	Gene:	mylk / 101730432	XenbaseID:	XB-GENE-22164540	Length:	1969	Species:	Xenopus tropicalis

Alignment Length:	394	Identity:	126/394 - (31%)
Similarity:	214/394 - (54%)	Gaps:	39/394 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DSGKKAKAKDLKE--LNKQVSIEEKYNLHGLLGTGAFSEV-RLAESKDS---PGEHFAVKIIDKK 66
            |..:|....:.::  ||....:.:.|::...||||.|.:| |:.|.|..   .|:.|       |
Frog  1493 DDEEKESEPEYRDVTLNSSEKVTDYYDVEERLGTGKFGQVFRIVEKKSRKIYAGKFF-------K 1550

  Fly    67 ALKGKE-ESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGEL 130
            |...|: |.:..||.::          .||:     ||.:||.::.:|.|:.:.:|:|||:||||
Frog  1551 AYSAKDKEGIRQEIAIM----------NCLH-----HPKLVQCVDAFESKADMVMVLELVSGGEL 1600

  Fly   131 FDRIVEKG-SYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS- 193
            |:||:::. ..||::....::||.|.|:::|:||:||.||||||::..: ...:||.:.||||:
Frog  1601 FERIIDEDFELTEREVIKYMKQICEGVEFIHKQGIVHLDLKPENIMCVN-KTGTKIKLIDFGLAR 1664

  Fly   194 KMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILK 258
            ::|....:....|||.:|||||:..:|.|.:.|:||||||.|||:.|..||..:||....|.:..
Frog  1665 RLESCPNLKVLFGTPEFVAPEVINYEPIGYSTDMWSIGVICYILVSGLSPFMGDNDNETLANVTS 1729

  Fly   259 GDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKN 323
            ..::||...:|||||.||:.|.:|:...::.|..|.|.|.|:|:. .:.::........:::||.
Frog  1730 ATWDFDDEAFDEISEEAKNLISSLLKKDMKNRLNCTQCLQHSWLQ-QDTATMEAKKLSKDRMKKY 1793

  Fly   324 FAKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQS 388
            .|:.:|::..:|...|.::..||:.|..:|.    .||....::|.:|  ...:|...:|..::|
Frog  1794 MARRKWQKTGHAVRAIGRLSSMAMISGLSAR----KSSGSAPSSPLSA--ELEANEEDNQAFLES 1852

  Fly   389 HAQE 392
            ..:|
Frog  1853 VTEE 1856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	103/280 (37%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	103/277 (37%)
mylk	XP_031749515.1	Ig	1865..1952	CDD:416386
		Ig strand A	1865..1868	CDD:409353
		Ig strand A'	1870..1873	CDD:409353
		Ig strand B	1877..1886	CDD:409353
		Ig strand C	1891..1897	CDD:409353
		Ig strand C'	1900..1902	CDD:409353
		Ig strand D	1908..1913	CDD:409353
		Ig strand E	1916..1924	CDD:409353
		Ig strand F	1932..1939	CDD:409353
		Ig strand G	1942..1952	CDD:409353
		Ig strand A	255..258	CDD:409353
		I-set	256..345	CDD:400151
		Ig strand A'	261..265	CDD:409353
		Ig strand B	273..281	CDD:409353
		Ig strand C	286..291	CDD:409353
		Ig strand C'	294..296	CDD:409353
		Ig strand D	302..307	CDD:409353
		Ig strand E	310..315	CDD:409353
		Ig strand F	324..332	CDD:409353
		Ig	354..441	CDD:416386
		Ig strand A	354..357	CDD:409353
		Ig strand A'	363..366	CDD:409353
		Ig strand B	371..379	CDD:409353
		Ig strand C	385..389	CDD:409353
		Ig strand C'	392..395	CDD:409353
		Ig strand D	399..403	CDD:409353
		Ig strand E	407..412	CDD:409353
		Ig strand F	420..428	CDD:409353
		Ig strand G	431..441	CDD:409353
		Ig	461..550	CDD:416386
		Ig strand A	461..464	CDD:409353
		Ig strand A'	469..472	CDD:409353
		Ig strand B	478..485	CDD:409353
		Ig strand C	491..496	CDD:409353
		Ig strand C'	499..501	CDD:409353
		Ig strand D	506..510	CDD:409353
		Ig strand E	516..520	CDD:409353
		Ig strand F	529..537	CDD:409353
		Ig strand G	540..550	CDD:409353
		I-set	559..645	CDD:400151
		Ig strand A	562..565	CDD:409353
		Ig strand A'	567..571	CDD:409353
		Ig strand B	574..583	CDD:409353
		Ig strand C	589..594	CDD:409353
		Ig strand C'	597..600	CDD:409353
		Ig strand D	603..608	CDD:409353
		Ig strand E	609..617	CDD:409353
		Ig strand F	624..632	CDD:409353
		Ig strand G	635..645	CDD:409353
		MSCRAMM_ClfA	<869..1146	CDD:411231
		I-set	1155..1244	CDD:400151
		Ig strand A'	1160..1164	CDD:409353
		Ig strand B	1172..1180	CDD:409353
		Ig strand C	1185..1190	CDD:409353
		Ig strand C'	1193..1195	CDD:409353
		Ig strand D	1201..1206	CDD:409353
		Ig strand E	1209..1214	CDD:409353
		Ig strand F	1223..1231	CDD:409353
		Ig strand G	1234..1244	CDD:409353
		Ig	1291..1388	CDD:416386
		Ig strand A	1291..1294	CDD:409353
		Ig strand A'	1299..1303	CDD:409353
		Ig strand B	1307..1316	CDD:409353
		Ig strand C	1320..1326	CDD:409353
Ig strand C'	1329..1331	CDD:409353
Ig strand D	1337..1342	CDD:409353
Ig strand E	1346..1351	CDD:409353
Ig strand F	1359..1367	CDD:409353
Ig strand G	1370..1380	CDD:409353
FN3	1384..1476	CDD:238020
PKc_like	1515..1773	CDD:419665	103/280 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010