DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and mylk5

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_005164113.1	Gene:	mylk5 / 100003770	ZFINID:	ZDB-GENE-050309-74	Length:	856	Species:	Danio rerio

Alignment Length:	390	Identity:	123/390 - (31%)
Similarity:	200/390 - (51%)	Gaps:	54/390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GKKAKAKDLKELNKQVSIEEK----YNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKG 70
            |...:.|.::.:|..:..:.|    ||:...||.|.|.:|.....|.: |...|.|....:..|.
Zfish   409 GDSREEKPVEYVNVTIDTQHKLTDHYNVLEKLGVGKFGQVFRMTHKVT-GRECAGKFYKSRRAKD 472

  Fly    71 KEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIV 135
            : |:...||.::      :|         |.||.:||.|..|::|:::.:|||.|.|||||:|||
Zfish   473 R-EAARKEIELM------NF---------LHHPKLVQCLAAYDNKAEMVMVMEYVAGGELFERIV 521

  Fly   136 EKG-SYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLS-KMEDS 198
            :.. .:||..:...:|||||.:.|||:|.::|.||||||::... ...|:|.|.||||: |::.:
Zfish   522 DDSFEHTEVSSVGYMRQILEGIKYMHQQNILHLDLKPENIVCVD-RTGSQIKIIDFGLACKLDPN 585

  Fly   199 GIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEF 263
            ..:....|||.:|||||:..:......|:||:|||.||||.|..||..|:|....|.:....:||
Zfish   586 TPLKVMQGTPEFVAPEVINFEAVTLTTDMWSVGVICYILLSGESPFQGESDTETLALVTAAQWEF 650

  Fly   264 DSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAW-----ISGNEASSRNIHGTVSEQLKKN 323
            |...::||::.||.||.:|:.....:|.:|::||.|.|     :..:.:..:|:.   .:::||.
Zfish   651 DEESFEEITDMAKGFISSLLNKDPRRRLSCEEALAHDWLGFLCVDNSSSGGKNLS---KDKMKKF 712

  Fly   324 FAKSRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTAATGAWTSNVLSSQQSVQS 388
            ..:.:||:   ....:..::|||:.|...|:                   |.||.|..::|::||
Zfish   713 LTRQKWKK---TGKALLALKRMAILSKPEAS-------------------ASTSPVHETEQALQS 755

Fly 389 388
Zfish 756 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	102/279 (37%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	102/277 (37%)
mylk5	XP_005164113.1	I-set	55..141	CDD:254352
		Ig	72..137	CDD:143165
		Ig	217..314	CDD:299845
		I-set	218..306	CDD:254352
		FN3	310..404	CDD:238020
		S_TKc	434..689	CDD:214567	101/272 (37%)
		STKc_MLCK	440..689	CDD:271005	99/266 (37%)
		I-set	764..855	CDD:254352
		Ig	781..852	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010