Protein Alignment lgs and Bcl9l

DIOPT Version :9

• Sequence 1: NP_651922.1
• Gene: lgs / 43791
• FlyBaseID: FBgn0039907
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_084532.2
• Gene: Bcl9l / 80288
• MGIID: 1933114
• Length: 1494
• Species: Mus musculus
• Alignment Length: 1695
• Identity: 345/1695 - (20%)
• Similarity: 526/1695 - (31%)
• Gaps: 617/1695 - (36%)

  Fly    44 RSSPKTLNSEPFSTLSPDQIK-LTPEEGTEKSGLSTSDKAATGGAPGSGNNLPEGQTMLRQNSTS 107
            |.:|.:....|.....|...| :.||     :.|:...|...|||.....|:.:|.|
Mouse    16 REAPGSPPLSPRGHCPPAPAKPMHPE-----NKLTNHGKTGNGGAQSQHQNVNQGPT-------- 67

  Fly   108 TINSCLVASP-QNSSEHSNSSNVSATVGLTQMVDCDEQSKKNKCSVKDEEAEISS-NKAKGQAAG 170
                |.:.|. ..:..|...:|               |...:..|:|:.:|.:|. :..||:
Mouse    68 ----CNLGSKGVGAGSHGAKAN---------------QISPSNSSLKNPQAGVSPFSSLKGK--- 110

  Fly   171 GGCETGSTSSLTVKEEPTDVLGSLVNMKKEERENHSPTMSPVGFGSIGNAQDNSATPVK------ 229
                        ||.|.:..:.|     .|:||..:|::            |:.|..|.
Mouse   111 ------------VKRERSVSVDS-----GEQREAGTPSL------------DSEAKEVAPRSKRR 146

  Fly   230 --IERISNDSTTEKKGSSLTMNNDE--MSMEGCNQLNPDFINESLNNPAISSILVSGV------- 283
              :||....|..|......:..:|:  .:...||..:|..:...|.....:.:.:|..
Mouse   147 CVLERKQPYSGDEWCSGPDSEEDDKPIAAAHNCNVADPAMVTPQLGPGQTAQLPLSESSAPGPQH 211

  Fly   284 GPIPGI-----GVGAGTGNLLTANANGISSGSSNCLDYMQQQNHIFVFSTQLANKGAESVLSGQF 343
            ||.||:     |.|.|          |:..        ......::||:|.|||..||:||.|:.
Mouse   212 GPQPGLRPDVPGGGGG----------GVPG--------KPPSQFVYVFTTHLANTAAEAVLQGRA 258

  Fly   344 QTIIAYHCTQPATKSFLEDF----FMKNPLKINKLQRHNSVGMPWIGMGQVGLTPPNPVA----- 399
            ::|:||| .|...::.|:..    ....||.:|.    .|.|.|   ..|....||.|.|
Mouse   259 ESILAYH-QQNVPRAKLDQAPKVPPTPEPLPLNT----PSAGTP---QSQPPPLPPPPPAPGSAP 315

  Fly   400 -KITQQQPHTKTVGLLKPQFNQHENSKRSTVSAPSNSFVDQSDPMGNETELMCWEGGSSNTSRSG 463
             .:..:.|...|...|.|          ::|.|.|..                  ||:..|
Mouse   316 PALPPEGPPEDTSQDLAP----------NSVGAASTG------------------GGTGGT---- 348

  Fly   464 QNSRNHVDSISTSSESQAIKILEAAGVDLGQVTKGSDPGLTTENNIVSLQGVKVP---------- 518
                 |.::.:.::.:..:             ..|.|||....:   :|.|...|
Mouse   349 -----HPNTPTAATANNPL-------------PPGGDPGSAPGS---ALLGEATPTGNGQRNLVG 392

  Fly   519 DENLTPQQRQHREEQLAKIKKMNQFLFPENENSVGANVSSQITKIPGDLMMGMSGGGGGSIINPT 583
            .|.|:.:|.:|||..|..::.:.:.|....|..              ..:.|..||.|..  .|
Mouse   393 SEGLSKEQLEHRERSLQTLRDIERLLLRSGETE--------------PFLKGPPGGAGEG--GP- 440

  Fly   584 MRQLHMPGNAKSELL---SATSSGLSEDVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVGVVTGT 645
                  |..|.|...   ||...||.:                     .:..:|     .:::.|
Mouse   441 ------PAQAPSAAQPPPSAPPGGLKK---------------------YEEPLQ-----SMISQT 473

  Fly   646 TAAGVNVNMHCSSSGAPNGNMMGSSTDMLASFGNTSCNVIGTAPDMSKEVLNQDSRTHSHQGGVA 710
            .:.|.....| ...|.|.|..||...:|:                  .:.|.|||.|..
Mouse   474 QSLGGPPLEH-EVPGHPQGGDMGQQMNMM------------------MQRLGQDSLTPE------ 513

  Fly   711 QMEWSKIQHQFFEER--------LKGGKPRQVTGTVVPQQQTPSGSGGNSLNNQVRPLQGPPPPY 767
            |:.|.|:|.:::||:        |.||:|          .|...|.||       ...:||||||
Mouse   514 QVAWRKLQEEYYEEKRRKEEQIGLHGGRP----------LQDMVGMGG-------MMGRGPPPPY 561

  Fly   768 HS---------IQRSASVPIATQSP---NPSSPNNLSLPSPRTTAAVMGLPTNS----PSMDGTG 816
            ||         :......|:..|.|   .|..|    .|.||       .|.|.    |...|..
Mouse   562 HSKPGDQWPPGMGAQLRGPMDVQDPMQLRPGPP----FPGPR-------FPGNQMQRVPGFGGMQ 615

  Fly   817 SLSGSVP-QANTSTVQAGTT-----TVLSANKNCFQADTPSPSNQNRSRNTGSSSV----LTHNL 871
            |:...|| .|....|:.|..     ..:....|..|...|.|..|..:....:..|    |.|.|
Mouse   616 SMPMEVPMNAMQRPVRPGMAWNEDLPPIGGPSNFAQNAVPYPGGQGEAERFMTPRVREELLRHQL 680

  Fly   872 ----SSNPSTPLS--------------------HLSPKEFESFGQSSAGDNM------------K 900
                |.....||.                    .:.|..|.  ||.:.||.:            :
Mouse   681 LEKRSMGMQRPLGMAGSGMGQSMEMERMIQAHRQMDPAMFP--GQMTGGDGLAGTPMGIEFGGGR 743

  Fly   901 SRRPSPQGQRSPVNSLIEANKDVRFAASSPG-FNPHPHMQSNSNSALNAYKMGSTNIQMERQASA 964
            .....|.||    :.|.|.:..:     .|| .|.:.::..|.|..||........:.|.::...
Mouse   744 GLLSPPMGQ----SGLREVDPPM-----GPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRG 799

  Fly   965 QGGSV--------QFSR-RSDN------------IPLN-PN------SGNRPPPNKMTQN----- 996
            .|..:        :.:| |:.|            :|.. ||      ||.:.|...|.|:
Mouse   800 PGDMMGPQGLSPEEMARVRAQNSSGMMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMPQDMGNTP 864

  Fly   997 --FDPISSLAQMSQQLTSCVSSM-----GSPAGTGGMTMMGGPG--PSDINIEHGIISGLDGSGI 1052
              |.|..|...|....|:.:|.|     .:|.|:..:....|.|  |||:.|.   |:.:...|:
Mouse   865 DMFSPDQSSVPMGTVGTARLSHMPLPPASNPPGSVHLASNRGLGRRPSDLTIS---INQMGSPGM 926

  Fly  1053 -----DTINQ-------------------------------NNCHSMNVVMNSMG--------PR 1073
                 .|::|                               ....|..|:.:|:|        .|
Mouse   927 GHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLSSSLGVRSPTGSPSR 991

  Fly  1074 MLNPKMCVAGGPNGPPGF--NPNS--PNGGLREN-----SIGSGCGSANSSNFQGVVPPGA--RM 1127
            :.:|.|.|..     ||:  :|.:  |:.|:.:|     ||.|.....|..  ||.:||.|  ..
Mouse   992 LKSPSMAVPS-----PGWVASPKTAMPSPGVSQNKQPPLSINSSSTLGNVE--QGALPPSAPRNS 1049

  Fly  1128 MGRMPVNFGSN-FNPNIQVKASTPNTIQYMPVRAQNANNNNNNGANNVRMPPSLEFLQ--RYANP 1189
            ....|.|..|. .||::.. .|:|:     |..:||              |.||...|  :||.|
Mouse  1050 SSAPPANPSSGLMNPSLPF-TSSPD-----PTPSQN--------------PLSLMMSQMSKYAMP 1094

  Fly  1190 QMGAVGNGS---------------PICPPSASDGTPGMPGLMAGPGAGGMLMNSSGEQHQNKITN 1239
            ....:.:.:               |:.||..       |...:|||...   |...:.|.
Mouse  1095 SSTPLYHNAIKTIATSDDELLPDRPLLPPPP-------PPQGSGPGISN---NQPNQMHM----- 1144

  Fly  1240 NPGASN---GINFFQNCNQMSIVDEEGGLPGHDGSMNIGQPSMIRGMRPHA----MRPNVMGARM 1297
            ||.|:.   |:|                |||.....:...|:|:....|..    :.||..|...
Mouse  1145 NPAAAQSPMGMN----------------LPGQQPLSHEPPPTMLPSPTPLGSNIPLHPNAQGTGG 1193

  Fly  1298 PPVNRQIQFAQSSDGIDCVGDPSSFFTNASCNSAGPHMFGSAQQANQPKTQ--HIKNIPS----- 1355
            ...|..:.         ..|.|.|.  ||.|   ||....|...:..|:.|  |....|:
Mouse  1194 SSQNSMMM---------APGGPDSL--NAPC---GPVPSSSQMMSFPPRLQQPHGAMAPTGAGGP 1244

  Fly  1356 GMCQN-QSGLAVAQGQIQLHGQG------HAQGQSLIGPTNNNLMSTAGSVSATNGVSGI----- 1408
            |:.|: .||:|:....:.....|      |..|:.:.|     .|..|.......||:.:
Mouse  1245 GLQQHYPSGMALPPEDLPTQPPGPIPPQQHLMGKGMTG-----RMGDAYPPGVLPGVASVLNDPE 1304

  Fly  1409 --NFVGPSST-----DLKY---AQQYHSFQQQLYATNTRSQ----QQQHMHQQHQSNMI-----T 1454
              ..:.|:.|     ||..   :::..|..|  |...:.:|    |..::|..:..||:     :
Mouse  1305 LSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQ--YFPKSENQPPKAQPPNLHLMNLQNMMAEQTPS 1367

  Fly  1455 MPPNL 1459
            .||||
Mouse  1368 RPPNL 1372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370	8/37 (22%)
Bcl9l	NP_084532.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..236		55/301 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..496		59/336 (18%)
		Necessary for interaction with CTNNB1	302..530		64/354 (18%)
		BCL9	395..429	CDD:371566	8/47 (17%)
		PHA03247	<869..1351	CDD:223021	117/563 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	905..1082		44/206 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1113..1206		25/132 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050