DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lgs and Bcl9

DIOPT Version :9

Sequence 1:	NP_651922.1	Gene:	lgs / 43791	FlyBaseID:	FBgn0039907	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_084209.3	Gene:	Bcl9 / 77578	MGIID:	1924828	Length:	1425	Species:	Mus musculus

Alignment Length:	1711	Identity:	333/1711 - (19%)
Similarity:	513/1711 - (29%)	Gaps:	693/1711 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PEGQTMLRQNSTSTINSCLV---------ASPQNSSEHSNSSNVSATVGLTQMVDCDEQSKKNKC 150
            |.|.|   |:|..:....:|         .:||..|:.||......:...:|...||.:|
Mouse    12 PSGNT---QSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKPGGSASQSQPSPCDSKS----- 68

  Fly   151 SVKDEEAEISSNKAKGQAAGGGCETGSTSSLTVKEEPTDVLGSLVNMKKEERENHSPTMSPVGFG 215
                                ||                                |:|...|...|
Mouse    69 --------------------GG--------------------------------HTPKALPGPGG 81

  Fly   216 SIG--NAQDNSAT-PVKIER-ISNDSTTEKKGSSLTMNNDEMSMEGCNQLNPDFINESLNNPAIS 276
            |:|  |...|.|. ..|.|| ||.||..::...:   .||:..::.||..:.....||.:.|
Mouse    82 SMGLKNGAGNGAKGKGKRERSISADSFDQRDPGT---PNDDSDIKECNSADHIKSQESQHTP--- 140

  Fly   277 SILVSGVGPIPGIGVGAGTGNLLTA-NANGISSGSSNCLDYMQQQNH----IFVFSTQLANKGAE 336
                           .:.|.:..|| .::..|.|.:...:.:..|..    ::||||::|||.||
Mouse   141 ---------------HSMTPSTATAPRSSTPSHGQTPAPEPISAQKTPAKVVYVFSTEMANKAAE 190

  Fly   337 SVLSGQFQTIIAYHCTQPATKSFLEDFFMKNPLKINKLQRHN---SVGMPWIGMGQVGLTPPNPV 398
            :||.||.:||:::|              ::| :..:|.:|..   :..:|.:      ...|.|:
Mouse   191 AVLKGQVETIVSFH--------------IQN-ISNSKSERSTAPLNTQIPTL------RNDPKPL 234

  Fly   399 AKITQQQPHTKTVGLLKPQFNQHENSKRST-------VSAPSNS------FVDQSDPMGNETELM 450
                .|||....        ||.:||.::.       :.||:..      .:|:..| |.|.:|:
Mouse   235 ----PQQPPAPA--------NQDQNSSQNARLQPTPPIQAPAPKPTAAPRPLDRESP-GVENKLI 286

  Fly   451 CWEG--GSSN---TSRSGQNSRNHVDSISTSSESQAIKILEAAGVDLGQVTKGSDPGLTTENNIV 510
            ...|  |||.   ...:|.||..:..:::..|:.......:........|:.|..|.| .||
Mouse   287 PPVGSPGSSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSGGEPPTL-GEN--- 347

  Fly   511 SLQGVKVPDENLTPQQRQHREEQLAKIKKMNQFLFPENENSVGANVSSQITKIPGDLMMGMSGGG 575
                   || .|:.:|.:|||..|..::.:.:.|||:.:                :...|.:||
Mouse   348 -------PD-GLSQEQLEHRERSLQTLRDIQRMLFPDEK----------------EFTAGQTGG- 387

  Fly   576 GGSIINPTMRQLHMPGNAKSELLSATSSGLSEDVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVG 640
                  |......:.|..|.                |...|..|         ...|...|.|
Mouse   388 ------PQQNTGVLDGPQKK----------------PDGPIQAM---------MSQSQSLGKG-- 419

  Fly   641 VVTGTTAAGVNVNMHCSSSGAPNGNMMGSSTDMLASFGNTSCNVIGTAPDMSKEVL--NQDSRT- 702
                                      .|..||:.|.||......:..:||   |::  |..|::
Mouse   420 --------------------------PGPRTDVGAPFGPQGHRDVPFSPD---EMVPPNMSSQSG 455

  Fly   703 -----HSHQGGVAQMEWSKIQHQFFEERLKGGKPRQVTGTVVPQ---------QQTPSGSGGNSL 753
                 |.......|:.|.|:|.:|:||:.:  |..||   ||.|         |..|.|
Mouse   456 PIGPDHLDHMTPEQIAWLKLQQEFYEEKRR--KQEQV---VVQQCSLQDMMVHQHGPRG------ 509

  Fly   754 NNQVRPLQGPPPPYH----------------SIQRSASVPIATQSPNPSSPNNL----------- 791
                 .::||||||.                .|..|.|:|....:|:|:.|.:.
Mouse   510 -----VVRGPPPPYQMAPGEGWAPGAEPFPDGINISHSLPPRGMAPHPNMPGSQMRLPGFAGMIN 569

  Fly   792 ------SLPSPRTTAAVMGL--PTNSP-------------------------------------- 810
                  ::|:|.:...:.|:  |.:.|
Mouse   570 SEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLSEEMFQQQ 634

  Fly   811 ------------SMDG------------------------------------------------- 814
                        ||:|
Mouse   635 LAEKQLALPPGMSMEGIRPGMEMNRMIPGSQRHMEPGSNPIFPRIPVEGPLSPSRGDFPKGMPPQ 699

  Fly   815 -------------------------TGSLSGSVPQ---------ANTSTVQAGTTTVLSANKNCF 845
                                     .||.|..:||         .....::.|::.:|.|.
Mouse   700 IGPGRELEFGMVPGGMKGEVNLNVNMGSSSQMIPQKMREAGAGPEEMMKLRPGSSEMLPAQ---- 760

  Fly   846 QADTPSPSNQN--------------RSRNTGSSSVLTHNL------SSNPSTPLSHLSPKEFESF 890
            |...|.|..::              .|:..||:|.| .||      ....::.|||:.|.   ..
Mouse   761 QKMVPLPFGEHPQQEYGVGPRPFLPMSQGPGSNSGL-RNLREPIGPDQRTNSRLSHMPPL---PL 821

  Fly   891 GQSSAGDNMKSRRPSPQG-QRSPVNSLIEANKDVRFAAS---SPGFNPHPHMQSNSNSALNAYKM 951
            ..||...::.:..|..:| .|.|:        |:..|.|   |||.||   ::|.:...:.:..:
Mouse   822 NPSSNPTSLSTAPPVQRGLGRKPL--------DISVAGSQVHSPGINP---LKSPTMHQVQSPML 875

  Fly   952 GST--NIQMERQASAQGGSVQFSRRSDNIPLNPNSGN--------------RPPPNKMTQNFDPI 1000
            ||.  |::..:..|...|.:.....:.:|...|..|:              .|.|...:....|:
Mouse   876 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPL 940

  Fly  1001 SS----------LAQMSQQLTSCVSSMGSPAGTGGM-TMMGGPG--------------------- 1033
            .|          |...|..:...|.|.|.|..|... ..:..||
Mouse   941 QSPGIPPNHKAPLTMASPAMLGSVESGGPPPPTASQPASVNIPGSLPSSTPYPMPPEPTLSQNPL 1005

  Fly  1034 ------------PSDINIEHGIISGLDGSGIDT--INQNNCHSMNVVMNSMGPRMLNPKMCVAGG 1084
                        ||...:.|..|..:..|..|:  ....|..||| .|..||....||::   .|
Mouse  1006 SIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMN-SMPGMGINTQNPRI---SG 1066

  Fly  1085 PN------------------------GPPGFNPNSPNGGLRENSIGSGCGSANSSNFQGVVPPGA 1125
            ||                        .|....|:.|..|:   .:|.|..|.|.....|...|..
Mouse  1067 PNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPSIPPHGV---PMGPGLMSHNPIMGHGSQEPPM 1128

  Fly  1126 RMMGRMPVNFGSNFNPNIQVKASTPNTIQYMPVRAQNANNNNNNGANNVRMPPSLEFLQRYANPQ 1190
            ...|||  .|...|.|           :|..|.:....:|....|..|  .|..:.|      |.
Mouse  1129 VPQGRM--GFPQGFPP-----------VQSPPQQVPFPHNGPTGGQGN--FPGGIGF------PG 1172

  Fly  1191 MGAVGNGSPICPPSASD------GTPG-----------MPGLMAG--------PGAGGM------ 1224
            .|.:|..|.: |.|::|      |.||           ||.:...        |||.|:
Mouse  1173 EGPLGRPSNL-PQSSADPALCKPGGPGAPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLS 1236

  Fly  1225 -LMNSS-----------GEQHQNKITNNPGASNGINFFQNCNQMSIVDEEGG--LPGHDGSMNIG 1275
             ::.|.           ||....|....||.  |.:..|  ..||......|  |||..|...:|
Mouse  1237 RIIPSEKPSQTLQYFPRGEVPGRKQPQGPGP--GFSHMQ--GMMSDQAPRMGLALPGMGGPGPVG 1297

  Fly  1276 QPSMIRGMRP-----HAMRPN--VMGARMPPVNRQIQFAQSSDGIDCVGDPSSFFTNASCNSAGP 1333
            .|.:..|..|     :.|||.  :....|.|.:|.:..|||:     |..|::..||.:.
Mouse  1298 TPDIPLGTSPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQST-----VPGPATLMTNPAA----- 1352

  Fly  1334 HMFGSAQQANQPKTQHIKNIPSGMCQNQSGLAVAQGQIQLHGQGHAQGQSLIGPTNNNL----MS 1394
                           .:..|| |..:..:||....|.:...|...:. |.::||..|.:    |.
Mouse  1353 ---------------AVGMIP-GKDRGPAGLYTHPGPVGSPGMMMSM-QGMMGPQQNIMIPPQMR 1400

  Fly  1395 TAGSVSATNGVSGINFVGPSS 1415
            ..| ::|..|:.|.: .||.:
Mouse  1401 PRG-MAADVGMGGFS-QGPGN 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370	9/37 (24%)
Bcl9	NP_084209.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..172		46/240 (19%)
		Interaction with PYGO1. /evidence=ECO:0000250	177..205		16/41 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..441		63/341 (18%)
		BCL9	350..388	CDD:371566	12/60 (20%)
		Interaction with CTNNB1. /evidence=ECO:0000250	358..374		4/15 (27%)
		PHA03247	<570..1160	CDD:223021	103/628 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..624		5/46 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..1003		47/236 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1031..1051		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1199		14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1275		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050