DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lgs and Pygo1

DIOPT Version :9

Sequence 1:	NP_651922.1	Gene:	lgs / 43791	FlyBaseID:	FBgn0039907	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_082392.1	Gene:	Pygo1 / 72135	MGIID:	1919385	Length:	417	Species:	Mus musculus

Alignment Length:	366	Identity:	84/366 - (22%)
Similarity:	117/366 - (31%)	Gaps:	128/366 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1081 VAGGPNGPPGFNPNSPNGGLRENSIGSGCGSANSSNFQGVVPPGARMMGRMPVNFGSNFNPNI-Q 1144
            |.||.:|..|.  ..||     ..:||.......:|.||...|........|       |||. .
Mouse    15 VRGGDSGLDGL--GGPN-----IQLGSPDKKKRKANTQGSSFPPLSEYAPPP-------NPNSDH 65

  Fly  1145 VKASTP-----NTIQYMPVRAQN----ANNNNNNGANNVRMPPSLEFLQRYANPQMGAVGNGSPI 1200
            :.|:.|     |||.|.|:.:.|    .......|.:..||||       :..|:|     .||.
Mouse    66 LVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPP-------HVPPRM-----SSPY 118

  Fly  1201 CPPSASDGTP-GMPGLMAGPGAGGMLMNSSGEQHQNKITNNPGASNGINFFQNCNQMSIVDEEGG 1264
            |.|.:....| ..|....|.|.......:.| .|.|....||..:|            ::.::..
Mouse   119 CGPYSLRNQPHPFPQNPLGMGFNRPHAFNFG-PHDNSNFGNPPYNN------------VLTQDIN 170

  Fly  1265 LPG---HDGS---------MNIGQPSMIRGMRPHAMRPNVMGARMPPVNRQIQFAQSSDGIDCVG 1317
            :||   ..||         .|:||.|          .|::.....|                  |
Mouse   171 MPGQHFRQGSAENFSQIPPQNVGQVS----------NPDLASNFAP------------------G 207

  Fly  1318 DPSSFFTNASCNSA---GPHMFGSAQQANQPK---TQHIKNIPSGMCQNQSGLAVAQGQIQLHGQ 1376
            :.|:|.:....|.:   .|:.||.| :|..||   ||.....|:   ||.|
Mouse   208 NNSNFTSPLETNHSFIPPPNAFGQA-KAPLPKQDFTQGATKTPN---QNSS-------------- 254

  Fly  1377 GHAQGQSLIGPTN-----------NNLM---STAGSVSATN 1403
            .|....::..|.|           ||::   |.:||..|||
Mouse   255 THPPHLNMEDPVNQSNVELKNVNRNNVVQENSRSGSAEATN 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370
Pygo1	NP_082392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		18/69 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	35..41		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..265		26/135 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..318		6/12 (50%)
		PHD_PYGO1	339..395	CDD:277105
		Interaction with H3K4me2. /evidence=ECO:0000250	339..386
		Interaction with BCL9. /evidence=ECO:0000250	371..389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23194
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100