DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lgs and bcl9l

DIOPT Version :9

Sequence 1:	NP_651922.1	Gene:	lgs / 43791	FlyBaseID:	FBgn0039907	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_005159295.1	Gene:	bcl9l / 449532	ZFINID:	ZDB-GENE-040927-29	Length:	1531	Species:	Danio rerio

Alignment Length:	1682	Identity:	349/1682 - (20%)
Similarity:	527/1682 - (31%)	Gaps:	553/1682 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 MLRQNSTSTINSCLVASPQNSSEHSNSSNVSATVGLTQMVDCDEQSKKNKCS----VKDEEAEIS 160
            |..:|..|.....:.:..|:...:.|.:...|..|:        |..|...|    ||..  :||
Zfish     1 MHSENKLSNHGKQVTSGAQSQLPNVNQAQQQAPAGI--------QGSKGSASGNHGVKAN--QIS 55

  Fly   161 SN----KAKGQAAGGGCETGSTSSLTVKEEPTDV-LGSLVNMKKEERENHSPTMSPVGFGSIGNA 220
            ..    |...|..|||   |...:...:|....: .|       ::||:.:|.:.|       :|
Zfish    56 PGNPGLKTLNQTGGGG---GMMKTKAKRERSVSIDTG-------DQRESLTPVLEP-------DA 103

  Fly   221 QDNSATPVK----IERISNDSTTEKKGSSLTMNNDEMSMEGCNQLNPDFINESLNNPAISSILVS 281
            :.......|    :||....|..|....:.|...||..:...::       |.:..|:......|
Zfish   104 KVEGVMRSKRRCVLERKQPYSGDEWCSGAETEEEDEKPLSATHR-------EHVMCPSQGHSGSS 161

  Fly   282 GVGPI--PGIGVGAGTGNLLTANANGISSGSSNCLDYMQQQNHIFVFSTQLANKGAESVLSGQFQ 344
            ..|.:  || |.|.|:|:         ..|....|.....|..::||:|.|||..||:|:.|...
Zfish   162 TTGHVSDPG-GPGLGSGH---------GPGIRTDLHSRPPQQVVYVFTTSLANSAAEAVMHGHTD 216

  Fly   345 TIIAYHCTQ-PATKSFLEDFFMKNPLKINKLQRHNSVGMPWIGMGQVGLTPPNPVAKITQQQPHT 408
            :|:.||... |.||.   |.......|::.|..|.|...          :||....|.....|..
Zfish   217 SILLYHQQNVPRTKL---DQQSTGVGKVSNLAEHISSSH----------SPPIGTPKSQSGTPRP 268

  Fly   409 KTVGLLKPQFNQHENSKRSTVSAPSNSFVDQSDPMGNETELMCWEGGSSNTSRSGQNSRNHVDSI 473
            .:||.:         ......|.||::....|:|....      .||.:    |..|.|:.|.::
Zfish   269 ASVGGV---------GHLPGTSTPSSTGHPDSEPAQTH------RGGGT----SSNNGRSAVHTL 314

  Fly   474 ST-SSESQAIKILEAAGVDL-GQVT-KGSDPGLTTENNIVSL-----QGVKVPDEN---LTPQQR 527
            .. :|..|::.:....|||. |.:. .|:....:|..:::|.     .|.:|...|   |:.:|.
Zfish   315 GLGNSGPQSVGVSGTEGVDRPGAIPHHGAGVSPSTSPSVLSALRQSELGQRVGPGNTDGLSKEQL 379

  Fly   528 QHREEQLAKIKKMNQFLFPENENSVGANVSSQITKIPGDLMMGMSGGGGGSIINPTMRQLHMPGN 592
            :|||..|..::.:.:.|...     |..|:.:..:       |.:|...|:.:|
Zfish   380 EHRERSLQTLRDIERLLLRS-----GTGVAQEDPR-------GPNGNPNGTNVN----------- 421

  Fly   593 AKSELLSATSSGLSEDVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVGVVTGTTAAGVNVNMHCS 657
                                             |||..     ..|.|:..|....|:..|.|.:
Zfish   422 ---------------------------------NNNSN-----DGGRGLEDGEIGGGIPGNCHIN 448

  Fly   658 SSGAPNGNMMGSS---TDMLASFGNTSCNVIGTAPDMSKEVLNQDSRTHSHQ------------- 706
            ::|.|....:|..   .:.|.|..:.:.|:.|...|.|....:.....|||.
Zfish   449 NAGMPGMPPVGGMKKYEEPLQSIISQTQNLGGPGLDDSLMGPHHGMPPHSHHLSSPSGLDMGPLL 513

  Fly   707 --GGVA--QMEWSKIQHQFFEE--RLKGGKPRQVTG--TVVPQQQTPSGSGGNSLNNQVRP--LQ 761
              .||.  |:.|.|:|.::::|  |.....|.|...  .::|:...|.|.          |  ::
Zfish   514 GPEGVTPEQLAWRKLQEEYYQEKRRQHDMNPHQHPQHFRIMPEMGMPGGP----------PMLMR 568

  Fly   762 GPPPPYHS---IQRSASVPIA------------TQSPNPSSPNNLSL---PS-----PRTTAAVM 803
            ||||||||   .|:....|:.            .....|..|..|..   ||     |.:...|:
Zfish   569 GPPPPYHSKPGDQQWGPGPMVGGGMGGNARMMDMNQEGPRGPRFLGQMRGPSGGGGYPESPGGVL 633

  Fly   804 G----------------LPTNSPSMDGTGSLSGSVPQANTSTVQAGTTTVLSANKNCFQADTPSP 852
            |                |....|:|.|.|...|..|....           ......||.|...|
Zfish   634 GVEGLGPQRPPRPGMGWLEEIPPNMGGGGPFHGCYPPGGP-----------GGPPQHFQGDLDRP 687

  Fly   853 SN-------------QNRSRNTGSSSVLTHNLSSNPSTPLSHLSPKEFESFGQSSAGDNMKSRRP 904
            ..             |..||....:.:....:..||..|   ..|....:.|..|.||.|.
Zfish   688 MTREEIYRRIHRLDLQQMSRQQQQAGLGGPRMMDNPGGP---GFPNPGMAGGPPSRGDPMD---- 745

  Fly   905 SPQGQRSPVNSLI----------EANKDVRFAASSP---GFNPHPHMQSNSNSALNAYKM----- 951
                  .||:..|          :....:|....||   ..|.:..|..|....|.|.|:
Zfish   746 ------FPVSRTIMGSPIGGVGGDGGPTMRDIVDSPLGGNLNMNMGMNINQQQQLLAQKLRGGPG 804

  Fly   952 ---------------------GSTN----------IQMERQASAQGGSV---------------- 969
                                 |..|          :|...|:|..||.|
Zfish   805 VLGEMLNAEDISRIRASQNGRGGANKAMIPGPEGPLQFPNQSSFPGGQVDGPYLQQPGPDMYGPD 869

  Fly   970 -------QFSRRSDNIPLNPNS-----GNRPPPNKMTQNFDPISSLA-QMSQQLTSCVSS----- 1016
                   ..:.|..:||:|..|     |.|.||: :..:.:|:.|.| ..|.||.|...|
Zfish   870 QPGPPHLSSTSRLSHIPMNTGSRVTDLGARHPPD-LPISVNPMGSPAIPPSHQLKSPSLSQEPSP 933

  Fly  1017 -MGSP--AGTGGMTMMGGPGPSDINIEHGIISGLDGSGIDTINQNNCHSMNVVMNSMGPR----- 1073
             |.||  ||....:.:...||:     |..:....|:|  |.:..:..|..|:..|:|.|
Zfish   934 LMPSPSAAGLKSPSQLPQSGPT-----HPPLPAASGAG--TPSSTSIKSPQVMGPSLGLRSPSGS 991

  Fly  1074 ---MLNPKMCVAG------------GPNGPPGFNPNSPNGGLRENSIGSGCGSANSSNFQGVVPP 1123
               :.:|.|.||.            .|.|||...... |||......|... ...|||...:..|
Zfish   992 PGHLKSPSMPVASPGWTASPKTAMPSPGGPPSVKVTG-NGGSSSTDTGMSL-PPRSSNSTPISQP 1054

  Fly  1124 GARMMGRMPVNFGSNFNPN-------------IQVKASTP------NTI-----QYMPVR-AQNA 1163
            ...:...||.....:..|:             ..:.:|||      .||     :.:|.| .|..
Zfish  1055 SNSINPSMPFTSSPDAPPSQNPLSLIMSQMSKYAMPSSTPLYHDAIKTIATSDDEMLPDRPLQPG 1119

  Fly  1164 NNNNNNGANNVRMPPSLEFLQ----RYANPQ--MGAVGNG---------SPICPPSASDGTPGMP 1213
            .|.:..|..|.:....|...|    .::.||  ||.|..|         .|:.|.....|.||||
Zfish  1120 TNMSVGGMGNHQSAQMLLSSQGAMGPHSGPQSPMGMVLQGGPPLSHDHPGPMLPSPNPMGIPGMP 1184

  Fly  1214 GLMAGPGAGGMLMNSSGEQHQNKITNNPGASNGINFFQNCN--QMSIVDEEGGLPGHDGSMN--- 1273
            ..:.|.|.                    |..:||.   .||  .|...::.||.|...|.::
Zfish  1185 SEIMGGGG--------------------GPPDGIG---PCNVSPMHTQNQMGGFPRIQGPLHSPI 1226

  Fly  1274 --IGQ-----------PSMI----RGM-------RPHAMRPNVMG-------------------- 1294
              :||           |..:    :||       :|.:..|..||
Zfish  1227 GGMGQQYPPRPDDVLPPQQMHLLSKGMSHQRPPHQPDSFPPMPMGDGPDLSEVIRPTHTGIPEFD 1291

  Fly  1295 -ARMPPVNR---QIQFAQSSDGID------CVGDPSSFFTNA----SCNSAGPHMFGSAQQANQP 1345
             :|:.|.::   .:|:...|:.:.      ..|.|....::|    ..:|:||      ..:|.|
Zfish  1292 LSRIIPADKPSSTLQYFPKSETMSQPQQNPHQGQPPPQVSSAQLLKQLSSSGP------PHSNIP 1350

  Fly  1346 KTQ-HIKNIPSGMCQNQ-------SGLAVAQGQIQLHGQGHAQGQSLIGPTNNNLMSTAGSVSAT 1402
            .:. ||.|:.:.|.:.|       .|:....|..|:..:|...|..: ||     |...|.:...
Zfish  1351 SSNPHIANLQNMMAEQQLPLHPSHCGMRPGMGMPQIGSRGMGSGGGM-GP-----MCHPGHMMGR 1409

  Fly  1403 NGVSGINFVGPSSTDLKYAQQYHSFQQQLYATNTRSQQQQH------MHQQHQSNMI 1453
            .|:|      |..   :..||:|..|||....|...|...|      ..|||..|:|
Zfish  1410 TGMS------PQQ---QLQQQHHHQQQQAMMANNLLQHPSHPPRGMLSPQQHPHNLI 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370	10/40 (25%)
bcl9l	XP_005159295.1	BCL9	373..411	CDD:288370	9/49 (18%)
bcl9l	XP_005159295.1	E_Pc_C	<974..1110	CDD:284226	29/137 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I4991
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.050