DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lgs and Bcl9

DIOPT Version :9

Sequence 1:	NP_651922.1	Gene:	lgs / 43791	FlyBaseID:	FBgn0039907	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_001101173.2	Gene:	Bcl9 / 310704	RGDID:	1306934	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	1695	Identity:	335/1695 - (19%)
Similarity:	511/1695 - (30%)	Gaps:	661/1695 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PEGQTMLRQNSTSTINSCLV---------ASPQNSSEHSNSSNVSATVGLTQMVDCDEQSKKNKC 150
            |.|.|   |:|..:....:|         .:||..|:.||......:...:|...||.:|
  Rat    12 PSGNT---QSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKPGGSASQSQPSPCDSKS----- 68

  Fly   151 SVKDEEAEISSNKAKGQAAGGGCETGSTSSLTVKEEPTDVLGSLVNMKKEERENHSPTMSPVGFG 215
                                ||                                |:|...|...|
  Rat    69 --------------------GG--------------------------------HTPKALPGPGG 81

  Fly   216 SIG--NAQDNSAT-PVKIER-ISNDSTTEKKGSSLTMNNDEMSMEGCNQLNPDFINESLNNPAIS 276
            |:|  |...|.|. ..|.|| ||.||..::...:   .||:..::.||..:.....||.:.|
  Rat    82 SMGLKNGAGNGAKGKGKRERSISADSFDQRDPGT---PNDDSDIKECNSADHIKSQESQHTP--- 140

  Fly   277 SILVSGVGPIPGIGVGAGTGNLLTA-NANGISSGSSNCLDYMQQQNH----IFVFSTQLANKGAE 336
                           .:.|.:..|| .::..|.|.:...:.:..|..    ::||||::|||.|:
  Rat   141 ---------------HSMTPSTATAPRSSTPSHGQTPAPEPIPAQKTPAKVVYVFSTEMANKAAD 190

  Fly   337 SVLSGQFQTIIAYHCTQPATKSFLEDFFMKNPLKINKLQRHN---SVGMPWIGMGQVGLTPPNPV 398
            :||.||.:||:::|              ::| :..:|.:|..   :..:|.:......| |..|.
  Rat   191 AVLKGQVETIVSFH--------------IQN-ISNSKTERSTAPLNTQIPSLRNDPKPL-PQQPP 239

  Fly   399 AKITQQQPHTKTVGLLKPQFNQHENSKRSTVSAPSNSFVDQSDPMGNETELMCWEG--GSSN--- 458
            |..:|.|..::...|......|....|.:....|    :|:..| |.|.:|:...|  |||.
  Rat   240 APASQDQNSSQNARLQPTPPIQAPAPKPAAAPRP----LDRDSP-GVENKLIPPVGSPGSSTPLP 299

  Fly   459 TSRSGQNSRNHVDSISTSSESQAIKILEAAGVDLGQVTKGSDPGLTTENNIVSLQGVKVPDENLT 523
            ...:|.||..:..:::..|:.......:........|:.|..|.| .||          || .|:
  Rat   300 PDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTL-GEN----------PD-GLS 352

  Fly   524 PQQRQHREEQLAKIKKMNQFLFPENENSVGANVSSQITKIPGDLMMGMSGGGGGSIINPTMRQLH 588
            .:|.:|||..|..::.:.:.|||:.:                :...|.:||       |......
  Rat   353 QEQLEHRERSLQTLRDIQRMLFPDEK----------------EFTAGQTGG-------PQQNTGV 394

  Fly   589 MPGNAKSELLSATSSGLSEDVMHPGDVISDMGAVIGCNNNQKTSVQCGSGVGVVTGTTAAGVNVN 653
            :.|..|.                |...|..|         ...|...|.|.|..|..
  Rat   395 LDGPQKK----------------PEGPIQAM---------MSQSQSLGKGPGPRTDV-------- 426

  Fly   654 MHCSSSGAPNG-----NMMGSSTDMLASFGNTSCNVIGTAPDMSKEVLNQDSRTHSHQGGVAQME 713
                  |||.|     ::..|..:|:....|:....||  ||            |.......|:.
  Rat   427 ------GAPFGPQGHRDVPFSPDEMVPPSMNSQSGPIG--PD------------HLDHMTPEQIA 471

  Fly   714 WSKIQHQFFEERLKGGKPRQVTGTVVPQ---------QQTPSGSGGNSLNNQVRPLQGPPPPYH- 768
            |.|:|.:|:||:.:  |..||   ||.|         |..|.|           .::||||||.
  Rat   472 WLKLQQEFYEEKRR--KQEQV---VVQQCSLQDMMVHQHGPRG-----------VVRGPPPPYQM 520

  Fly   769 ---------------SIQRSASVPIATQSPNPSSPNNL-----------------SLPSPRTTAA 801
                           .|..|.|:|....:|:|:.|.:.                 ::|:|.:...
  Rat   521 APGEGWAPGAEPFPDGINISHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPG 585

  Fly   802 VMGL--PTNSP--------------------------------------------------SMDG 814
            :.|:  |.:.|                                                  ||:|
  Rat   586 LSGVSWPDDVPKIPDGRNFPPGQGVFSGPGRGDRFPNPQGLSEEMFQQQLAEKQLALPPGMSMEG 650

  Fly   815 ----------------------------------------------------------------- 814

  Rat   651 IRPGMEMNRMIPGSQRHMEPGSNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGM 715

  Fly   815 ---------TGSLSGSVPQ---------ANTSTVQAGTTTVLSANKNCFQADTPSPSNQN----- 856
                     .||.|..:||         .....::.|::.:|.|.    |...|.|..::
  Rat   716 KGDVSLNVNMGSSSQMIPQKMREAGAGPEEMMKLRPGSSEMLPAQ----QKMVPLPFGEHPQQEY 776

  Fly   857 ---------RSRNTGSSSVLTHNL------SSNPSTPLSHLSPKEFESFGQSSAGDNMKSRRPSP 906
                     .|:..||:|.| .||      ....::.|||:.|.   ....||...::.:..|..
  Rat   777 GVGPRPFLPMSQGPGSNSGL-RNLREPIGPDQRTNSRLSHMPPL---PLNPSSNPTSLSTAPPVQ 837

  Fly   907 QG-QRSPVNSLIEANKDVRFAAS---SPGFNPHPHMQSNSNSALNAYKMGST--NIQMERQASAQ 965
            :| .|.|:        |:..|.|   |||.||   ::|.:...:.:..:||.  |::..:..|..
  Rat   838 RGLGRKPL--------DISVAGSQVHSPGINP---LKSPTMHQVQSPMLGSPSGNLKSPQTPSQL 891

  Fly   966 GGSVQFSRRSDNIPLNPNSGN--------------RPPPNKMTQNFDPISS----------LAQM 1006
            .|.:.....:.:|...|..|:              .|.|...:....|:.|          |...
  Rat   892 AGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMA 956

  Fly  1007 SQQLTSCVSSMGSPAGTGGM----------------TMMGGPG------------------PSDI 1037
            |..:...|.|.|.|..|...                ||...|.                  ||..
  Rat   957 SPAMLGSVESGGPPPPTASQPASVSIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSST 1021

  Fly  1038 NIEHGIISGLDGSGIDT--INQNNCHSMNVVMNSMGPRMLNPKMCVAGGPN-------------- 1086
            .:.|..|..:..|..|:  ....|..||| .|..||....||::   .|||
  Rat  1022 PLYHDAIKTVASSDDDSPPARSPNLPSMN-SMPGMGINTQNPRI---SGPNPVVPMPTLSPMGMT 1082

  Fly  1087 ----------GPPGFNPNSPNGGLRENSIGSGCGSANSSNFQGVVPPGARMMGRMPVNFGSNFNP 1141
                      .|....|:.|..|:   .:|.|..|.|.....|...|.....|||  .|...|.|
  Rat  1083 QPLSHSTQMPSPNAMGPSIPPHGV---PMGPGLMSHNPIMGHGSQEPPMVPQGRM--GFPQGFPP 1142

  Fly  1142 NIQVKASTPNTIQYMPVRAQNANNNNNNGANNVRMPPSLEFLQRYANPQMGAVGNGSPICPPSAS 1206
                       :|..|.:....:|....|..|  .|..:.|      |..|.:|..|.: |.|::
  Rat  1143 -----------VQSPPQQVPFPHNGPTGGQGN--FPGGIGF------PGEGPLGRPSNL-PQSSA 1187

  Fly  1207 D------GTPG-----------MPGLMAG--------PGAGGM-------LMNSS---------- 1229
            |      |.||           ||.:...        |||.|:       ::.|.
  Rat  1188 DPALCKPGGPGAPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFP 1252

  Fly  1230 -GEQHQNKITNNPGASNGINFFQNCNQMSIVDEEGG--LPGHDGSMNIGQPSMIRGMRP----HA 1287
             ||....|....||.  |.:..|  ..||......|  |||..|...:|.|.:..|..|    |:
  Rat  1253 RGEVPGRKQPQGPGP--GFSHMQ--GMMSDQAPRMGLALPGMGGPGPVGTPDIPLGTSPSMPGHS 1313

  Fly  1288 -MRPN--VMGARMPPVNRQIQFAQSSDGIDCVGDPSSFFTNASCNSAGPHMFGSAQQANQPKTQH 1349
             |||.  :....|.|.:|.:..|||:     |..|::..||.:.                    .
  Rat  1314 PMRPPAFLQQGMMGPHHRMMSPAQST-----VPGPATLMTNPAA--------------------A 1353

  Fly  1350 IKNIPSGMCQNQSGLAVAQGQIQLHGQGHAQGQSLIGPTNNNL----MSTAGSVSATNGVSGINF 1410
            :..|| |..:..:||....|.:...|...:. |.::||..|.:    |...| ::|..|:.|.:
  Rat  1354 VGMIP-GKDRGPAGLYTHPGPVGSPGMMMSM-QGMMGPQQNIMIPPQMRPRG-MAADVGMGGFS- 1414

  Fly  1411 VGPSS 1415
            .||.:
  Rat  1415 QGPGN 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370	9/37 (24%)
Bcl9	NP_001101173.2	BCL9	350..388	CDD:371566	12/60 (20%)
Bcl9	NP_001101173.2	PHA03247	<570..1160	CDD:223021	104/628 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000