DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lgs and PYGO1

DIOPT Version :9

Sequence 1:	NP_651922.1	Gene:	lgs / 43791	FlyBaseID:	FBgn0039907	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_001317255.1	Gene:	PYGO1 / 26108	HGNCID:	30256	Length:	419	Species:	Homo sapiens

Alignment Length:	501	Identity:	108/501 - (21%)
Similarity:	152/501 - (30%)	Gaps:	174/501 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   951 MGSTNIQM------ERQASAQGGSVQFSRRSDNI-PLNPNSGNRPPPNKMTQNFDPIS--SLAQM 1006
            :|...:|:      :|:|:.||.|  |...|:.. |.||||.:....|....|::.||  .|...
Human    25 LGGPGVQLGSPDKKKRKANTQGPS--FPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSS 87

  Fly  1007 SQQLTSCVSSMGSPAGTGGMT----------MMGGP--GPSDI-NIEHGIISGLDGSGIDTINQN 1058
            :..|     ..|.| |.||.:          .|..|  ||..: |..|.......|.|.     |
Human    88 NPYL-----GPGYP-GFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGF-----N 141

  Fly  1059 NCHSMNVVMNSMGPR----MLNPKMCVAGGPNGPPGFNPNSPNGGLRENSIGSGCGSANSSNFQG 1119
            ..|:.|     .||.    ..||..      |.....|.|.||...|:|.         :.||..
Human   142 RPHAFN-----FGPHDNSSFGNPSY------NNALSQNVNMPNQHFRQNP---------AENFSQ 186

  Fly  1120 VVPPGARMMGRMPVNFGSNFNPNIQVKASTPNTIQYMPVRAQNANNNNNNGANNVRMPPSLEFLQ 1184
            :.|..|..:..  .:..|||.|                  ..|:|..:...:|:..:||...|.|
Human   187 IPPQNASQVSN--PDLASNFVP------------------GNNSNFTSPLESNHSFIPPPNTFGQ 231

  Fly  1185 RYANP-----QMGAVGN---GSPICPPSASDGTPGMPGLMAGPGAGGMLMNSSGEQHQNKI-TNN 1240
            ..|.|     ..||..|   .|...||.                     :|.....:|:.| ..|
Human   232 AKAPPPKQDFTQGATKNTNQNSSAHPPH---------------------LNMDDTVNQSNIELKN 275

  Fly  1241 PGASNGINFFQNCNQMSIVDEEGGLPGHDGSMNIGQPSMIRG---------MRPHAMRPNVMGAR 1296
            ...:|.:|  |..::.|..:.....|. :|:.|  :|...||         ....::.||..|
Human   276 VNRNNAVN--QENSRSSSTEATNNNPA-NGTQN--KPRQPRGAADACTTEKSNKSSLHPNRHG-- 333

  Fly  1297 MPPVNRQIQFAQSSDGIDCVG--------DPSSFFTNASCNSAGPHMFGSAQQANQPKTQHIKNI 1353
                      ..|||.:...|        |..:....|||.                |..|  .|
Human   334 ----------HSSSDPVYPCGICTNEVNDDQDAILCEASCQ----------------KWFH--RI 370

  Fly  1354 PSGMCQNQSGLAVAQG-------------QIQLHGQGHAQGQSLIG 1386
            .:||.:...||..|:.             .:||.......|.|.:|
Human   371 CTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lgs	NP_651922.1	BCL9	521..559	CDD:288370
PYGO1	NP_001317255.1	PHD_PYGO1	341..397	CDD:277105	13/73 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23194
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100