DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and ZXDC

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens

Alignment Length:	995	Identity:	203/995 - (20%)
Similarity:	312/995 - (31%)	Gaps:	342/995 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 PLDECPHPLVQAQAQSQY--------------GGDYYDVADPQAREISEGRALIIGLGAPSTVST 283
            ||...|.||..:.|:.:.              .|:....:.|.|.:.|:|.:.::.|..|...:.
Human    23 PLRRAPAPLGASPARRRLLLVRGPEDGGPGARPGEASGPSPPPAEDDSDGDSFLVLLEVPHGGAA 87

  Fly   284 DDAQSSAPSHQLAGTGRALQTHQCKPMSPGTVGSSNLGAGRRSAPTTISKTFSQGQQSPQHSTTP 348
            .:|         ||:..|         .||:  ..||.              |:.:|.|.....|
Human    88 AEA---------AGSQEA---------EPGS--RVNLA--------------SRPEQGPSGPAAP 118

  Fly   349 SGGSTTPDIKYNNDKMANEIQLQLSRSSSAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRV 413
            .|....|                    :.|..||.                    |.:..::.|.
Human   119 PGPGVAP--------------------AGAVTISS--------------------QDLLVRLDRG 143

  Fly   414 GLGTHGVTGSANLGGSI---TPSS---DTKPHQC--QQCMKSFSSNHQLVQHIRVH---TGEKPY 467
            .|......|.|..|.:.   .|.:   .|..::|  .||..:|:..|||..|:..|   .|.:|:
Human   144 VLALSAPPGPATAGAAAPRRAPQASGPSTPGYRCPEPQCALAFAKKHQLKVHLLTHGGGQGRRPF 208

  Fly   468 KCSY--CDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRP 530
            ||..  |...|.....:::|.:.|...||:.|.:..||:.|..:.||:.|::.|:      :...
Human   209 KCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKAHMKGHE------QESL 267

  Fly   531 FHCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIGGPNATSCPVCHKLFLGTEALVDHMKH 595
            |.|.:|.:.|.|.:.|.:|.....:..            .|.....|.|.|.|:...||..|.:.
Human   268 FKCEVCAERFPTHAKLSSHQRSHFEPE------------RPYKCDFPGCEKTFITVSALFSHNRA 320

  Fly   596 VHKEKS----PPPGGSASSQFSELNQIVTGNGNGTGSSNEQIATQCTTESNSHQATVGSSLIDSF 656
            ..:|:.    ..||  .|.|:.:..::.....:.||    :....|.::|.....|..|.|:
Human   321 HFREQELFSCSFPG--CSKQYDKACRLKIHLRSHTG----ERPFICDSDSCGWTFTSMSKLL--- 376

  Fly   657 LGKRRTANH------PCPV--CGKHYVNEGSLRKHLACH------------------AENSQLTN 695
               |....|      .|||  |||.:.....|:.|...|                  |.:|...:
Human   377 ---RHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIH 438

  Fly   696 SLR----------MWPCSVCQAVFTHENGLLTHM---ESMRMDPKHQFAAQYVLSRAAAEQRERE 747
            |.:          ..|.|.|..:||.::.:..||   .|.|.|...|..|.             .
Human   439 SKKHVQDVGAPKSRCPVSTCNRLFTSKHSMKAHMVRQHSRRQDLLPQLEAP-------------S 490

  Fly   748 SLLAVTLAASSGAS--TRIGIADAGNVLPTGAHNSDGSNSKCPSPSANSECSSNGRLSSSTTSDQ 810
            ||...:..:|.|.|  |.:.:|...:..|..|..|.|         .:.|..::|.|:...||
Human   491 SLTPSSELSSPGQSELTNMDLAALFSDTPANASGSAG---------GSDEALNSGILTIDVTS-- 544

  Fly   811 DQDIDHGLSENENSNQNNIGSSTNNNNNCTSNNNASSHKMAELRLPGTGQY--TMDAELHVANRM 873
                              :.||...|   ...||:|...|..|.|......  ::|:.|.:....
Human   545 ------------------VSSSLGGN---LPANNSSLGPMEPLVLVAHSDIPPSLDSPLVLGTAA 588

  Fly   874 SLMAAAAAAVAASRPQDGVDTSAVPSAAVQAAVVNLAAAMRMNNSSNGATPYQQHHADHTQAHQT 938
            :::...:.:|      |.|.|       |.|..:....|:.|.|.|:.......:
Human   589 TVLQQGSFSV------DDVQT-------VSAGALGCLVALPMKNLSDDPLALTSN---------- 630

  Fly   939 HILQHAHPHHHQQQQAPQHQQQQLSHLLVH-THPSNSNSRSQSSPNINVPSLQNESTAASIAMNM 1002
                                    |:|..| |.|::|::..:   |.:||.|     .|.|
Human   631 ------------------------SNLAAHITTPTSSSTPRE---NASVPEL-----LAPI---- 659

  Fly  1003 NVHMMRGSLDPD-PSLGGMHGIEVLHQHQQQHHHHHHHHTSNYPQHAVTPTNQHTHPHPQTHQTA 1066
                   .::|| ||..|..|       ||:..|       ..|        |.|.|.|     |
Human   660 -------KVEPDSPSRPGAVG-------QQEGSH-------GLP--------QSTLPSP-----A 690

  Fly  1067 HHHTSPETALRMHQAEAILRSHTEAAFRLATGSGPDTGVKCEADQNQLNSNNAGNAGGNSGGNSQ 1131
            ..|.:.:|.|          |.....|.|.:|....|..:  |.|........| ||.|:|.:..
Human   691 EQHGAQDTEL----------SAGTGNFYLESGGSARTDYR--AIQLAKEKKQRG-AGSNAGASQS 742

  Fly  1132 QHR-----------FHASSN 1140
            ..|           ||||.|
Human   743 TQRKIKEGKMSPPHFHASQN 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	25/94 (27%)
		C2H2 Zn finger	441..461	CDD:275368	8/21 (38%)
		zf-H2C2_2	454..478	CDD:290200	9/28 (32%)
		C2H2 Zn finger	469..489	CDD:275368	4/21 (19%)
		zf-H2C2_2	481..508	CDD:290200	8/26 (31%)
		C2H2 Zn finger	497..519	CDD:275368	7/21 (33%)
		C2H2 Zn finger	533..557	CDD:275368	6/23 (26%)
		C2H2 Zn finger	576..594	CDD:275368	7/17 (41%)
		C2H2 Zn finger	667..687	CDD:275370	8/21 (38%)
		C2H2 Zn finger	702..719	CDD:275370	4/16 (25%)
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127		27/157 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174		5/22 (23%)
		C2H2 Zn finger	177..199	CDD:275368	8/21 (38%)
		zf-C2H2_aberr	208..353	CDD:293622	36/164 (22%)
		zf-C2H2	208..232	CDD:278523	5/23 (22%)
		C2H2 Zn finger	210..232	CDD:275368	4/21 (19%)
		C2H2 Zn finger	240..262	CDD:275368	7/21 (33%)
		C2H2 Zn finger	270..290	CDD:275368	6/19 (32%)
		COG5048	<284..443	CDD:227381	35/182 (19%)
		C2H2 Zn finger	299..321	CDD:275368	7/21 (33%)
		C2H2 Zn finger	333..352	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..382	CDD:275368	6/27 (22%)
		zf-H2C2_2	375..401	CDD:290200	9/31 (29%)
		C2H2 Zn finger	390..412	CDD:275368	8/21 (38%)
		COG5048	391..>584	CDD:227381	50/237 (21%)
		C2H2 Zn finger	420..442	CDD:275368	3/21 (14%)
		Required for transcriptional activation	579..688		36/196 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696		16/62 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756		6/30 (20%)
		Interaction with CIITA	781..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000