DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and Neu2

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	86/304 - (28%)
Similarity:	129/304 - (42%)	Gaps:	66/304 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 KP-HQCQQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLP 500
            || ..|..|.|||.....|..|:|.||||:|:.||.|.:.|...|.:|.|.|.||||||::|  .
  Fly   116 KPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQC--S 178

  Fly   501 DCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTHTSKELQLHLGVLQQHA 565
            .|.|:|....:|:.|::.|:      :.....|..|.|.|.|  ||             :|:||.
  Fly   179 HCPRSFTAGHHLKAHIQMHE------RRGSLRCPYCQKCFLT--SL-------------ILKQHL 222

  Fly   566 ALIGGPNATSCPVCHKLFLGTEALVDHMKHVHKEKSPPPGGSASSQF---SELNQIVTGNGNGTG 627
            |.........|..|.|.|.....|..||: ||:|:. ...|..|..|   :.|.:.::.|...:.
  Fly   223 ATHTDETQFKCSQCSKSFQVEHELWMHMR-VHQERL-FTCGHCSKDFALHAYLKRHLSRNARCSQ 285

  Fly   628 SSNEQIATQCTTESNSHQATVGSSLIDSFLGKRRTANHPCPVCGKHYVNEGSLRKHLACHAENSQ 692
            ||          ::::|:.          ||..:...  |..|.|.:.:..:|..||..|.:|..
  Fly   286 SS----------KASAHKT----------LGHSKALK--CGKCPKTFTDRSALSTHLKSHTKNKP 328

  Fly   693 L--------------TNSLRM-WPCSVCQAVFTHENGLLTHMES 721
            |              :|:.|. :.||.|...|:.::.||||:::
  Fly   329 LLEGPCKSSGSKPAHSNAQRKPFKCSSCPRTFSRKSALLTHLQT 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	33/74 (45%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..508	CDD:290200	13/26 (50%)
		C2H2 Zn finger	497..519	CDD:275368	6/21 (29%)
		C2H2 Zn finger	533..557	CDD:275368	7/23 (30%)
		C2H2 Zn finger	576..594	CDD:275368	6/17 (35%)
		C2H2 Zn finger	667..687	CDD:275370	6/19 (32%)
		C2H2 Zn finger	702..719	CDD:275370	7/16 (44%)
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	48/144 (33%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		zf-H2C2_2	133..158	CDD:290200	12/24 (50%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		zf-H2C2_2	162..185	CDD:290200	12/24 (50%)
		C2H2 Zn finger	177..197	CDD:275368	6/21 (29%)
		C2H2 Zn finger	205..225	CDD:275368	11/34 (32%)
		zf-C2H2_8	206..286	CDD:292531	25/96 (26%)
		C2H2 Zn finger	233..253	CDD:275368	7/20 (35%)
		C2H2 Zn finger	260..297	CDD:275368	9/56 (16%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100