DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and CG10543

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster

Alignment Length:	1169	Identity:	246/1169 - (21%)
Similarity:	390/1169 - (33%)	Gaps:	336/1169 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PQENEQLAGVQPEGPAAGS--GVVGNNSSMAISGTNSTVGSKAESSHIPQQHSEQQSYGSDSFRG 160
            |:.::.|||       |||  ...|::|:.:.||:.|.......|..|.:.:|..
  Fly   434 PEIDDMLAG-------AGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENNSHH---------- 481

  Fly   161 TQSPQLSSHHLLFNAAAAAAAAVHLKSTAMQNNLSPIGDQVQNNLRNYGQGSLNALCGIKPKQEM 225
                   :|||    :::::|.:.:......|::|       ||..|....||:
  Fly   482 -------THHL----SSSSSANLVINGLTSSNSIS-------NNNNNSNNVSLH----------- 517

  Fly   226 DAKTPLQPLDECPHPLVQAQAQSQYG-----GDYYDVADP------QAREISEGRALIIGLGAPS 279
                         .|.:..|||:|..     .|:..::.|      :|.:.:.|.|..|..|..|
  Fly   518 -------------RPQLTPQAQNQLAASMKPSDHIPISMPMENMDLKAGQAAHGTANAIMQGGSS 569

  Fly   280 TVSTDDAQSSAP----SHQLAGTGRALQTHQCKPMSPGTVGSSNLGAGRRSAPTTISKTFSQGQQ 340
            ::::...|...|    ::.|:..|..:|..|.:.:               :.|....:.....:.
  Fly   570 SLASQLHQQQKPYNSSNNPLSMMGGMMQQQQQQHV---------------AMPHHQRQMMMMPED 619

  Fly   341 SPQHSTTPSGGSTTPDIKY-----NNDKMANEIQLQLSRSSSAAAISE------RTLEECWSTLQ 394
            .|||..:.......|.:..     :...|:.::...|....:..:..|      ..|:|..:..|
  Fly   620 FPQHGASMMNSRQMPALAALSNLGDTPAMSGQLNSSLELDDNDLSADEDDDDLDHDLDELDAAKQ 684

  Fly   395 RLFMHKSAMQQIQQQIPRVGLGTHGVTGSANLGGSITPSSDTKP-HQCQQCMKSFSSNHQLVQHI 458
            :|....|:.....|..|    ..|| :||...||....|...|| :.|..|.||:.....|:.|.
  Fly   685 QLIDGGSSSSTSLQAPP----SQHG-SGSGGSGGQTPGSKKDKPSYNCLLCPKSYRKRKSLLDHY 744

  Fly   459 RVHTGEKPYKCSYC----DRRFKQLSHVQQHTR-LHTGERPYKCHLPDCGRAFIQLSNLQQHLRN 518
            ::|.|       ||    .|....|..:..|.| :|..|.|:.|.  .||.::.:......|:.:
  Fly   745 KMHPG-------YCHDCGQRNGNTLEEIIHHNRTMHVKEFPFVCE--TCGESYSRKQQFHAHVES 800

  Fly   519 HDAQVERAKNRPFHCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIG-GPNATSCPVCHKL 582
            |:    :.:.:.|.|..||..|..:.                ||||....| ..:...|.||.:.
  Fly   801 HN----KKEIKTFPCGECGLKFPQKK----------------LQQHFEETGHKADGAICEVCGEE 845

  Fly   583 FLGTEALVDHMKHVHKEKSPPPGGSASSQFSELNQIVTGNGNGTGSSNEQIATQCTTE------- 640
            |....||..|:..|||.          ..|.|.:   ..:...|..:|.:...|..||
  Fly   846 FQSKNALYQHIIRVHKR----------DNFFECH---ICHNRFTLKANLERHVQLHTEIKRPYVC 897

  Fly   641 -----------------SNSHQATVGSSLIDSFLGKRRTANHPCPVCGKHYVNEGSLRKHLACHA 688
                             ||:|        :|       .:...|.:|||.:.:..||::||..|:
  Fly   898 DLCGSSYFTYPALKEHYSNAH--------VD-------VSECKCTLCGKRFGSAKSLQRHLPSHS 947

  Fly   689 ENSQLTNSLRMWPCSVCQAVFTHENGLLTHMESMR-MDP------KHQFAAQ------------- 733
            |.       |...|:.|...|..:..|:.|.::|. .:|      |.:|...
  Fly   948 EE-------RPHCCNYCDQTFKWKTHLVRHKQTMHGNEPPPPKKGKQRFPKTSEEDMGSLPDMPG 1005

  Fly   734 ----YVLSRAAAEQRERESLLAVTLAASSGASTRIGIADAGNVLPTGAHNSDGSNSKCPSPSANS 794
                ....:||..:.:.::..|...||||....:.|.| |....|.....:.|...:.|..:|
  Fly  1006 PPPVKASKKAATSKAKAQAAAAAAAAASSQQQQQKGSA-ATPTPPPPVSTTPGCLQQDPFNAA-- 1067

  Fly   795 ECSSNGRLSSSTTSDQDQDIDHGLSENENSNQNNIGSSTNNNNNCTSNNNASSHKMAELRLPGTG 859
            ..|||...||:.::.|     |.:|.:| |.||:|.:.:.|               ||.:.|  |
  Fly  1068 MVSSNSSQSSTASTSQ-----HSVSTSE-SQQNSIYNQSFN---------------AEKQQP--G 1109

  Fly   860 QYTMDAELHVANRMSLMAAAAAAVAASRPQDGVDTSAVPSAAVQAAVVNLAAAMRMNN------- 917
            |......||..:       ........:.|......|:|.:.|....::|   .|||:
  Fly  1110 QQQPQNTLHQQH-------PTPPPPQQQQQQQQQQQALPQSRVGPGELHL---QRMNSFGQDGQF 1164

  Fly   918 ---SSNGATPYQQHHADHTQAHQTHILQHAHPHHHQQQQAPQHQQQQLSHLLVHTHPSNSNSRSQ 979
               |:..|..||||..         |.|:......||||..|..|||..|.|......:..|.:.
  Fly  1165 HFESNPAAGAYQQHQL---------ISQYQQQQQQQQQQQQQQPQQQQQHHLAQQQQQHMRSHTP 1220

  Fly   980 SSPNINVPS-LQNESTAASIAMNMNVHMMRGSLDPDPSLGGMHGIEVL-HQH----QQQHHHH-- 1036
            .||:...|| ||.:                   .|.......|.:..: |||    ||||.|:
  Fly  1221 QSPHPPHPSQLQQQ-------------------QPQQHFSSPHHMPPMHHQHQLMMQQQHRHNQR 1266

  Fly  1037 ---HHHHTSNYPQHAVTPTNQHTHPHPQTHQTAHHHT---SPETA----------LRMHQAEAIL 1085
               |||..:...|      .||..|   :|...|.|.   ||:.|          .:..|.:..|
  Fly  1267 SPLHHHPAAQQLQ------QQHQQP---SHSPQHQHARLQSPQPAPVQQQQQQQQQQQQQQQQFL 1322

  Fly  1086 RSHTEAAFRLATGSGPDTGVKCEADQNQLNSNNAGNAGG---NSGGNSQQHRFHASSNHQENQR 1146
            :......:.......|....:.|...|:.....:....|   |...:.||.:..|.|..|:.|:
  Fly  1323 QQQAADTWGNMNFGNPPNNQQVELKDNKFYIVESAEFLGLPMNVPPSPQQQQQQAVSKPQQQQQ 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	23/87 (26%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	7/27 (26%)
		C2H2 Zn finger	469..489	CDD:275368	6/24 (25%)
		zf-H2C2_2	481..508	CDD:290200	8/27 (30%)
		C2H2 Zn finger	497..519	CDD:275368	4/21 (19%)
		C2H2 Zn finger	533..557	CDD:275368	4/23 (17%)
		C2H2 Zn finger	576..594	CDD:275368	7/17 (41%)
		C2H2 Zn finger	667..687	CDD:275370	8/19 (42%)
		C2H2 Zn finger	702..719	CDD:275370	4/16 (25%)
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	6/19 (32%)
		C2H2 Zn finger	751..773	CDD:275368	5/21 (24%)
		C2H2 Zn finger	781..801	CDD:275368	4/21 (19%)
		PHA00733	<804..860	CDD:177301	17/71 (24%)
		C2H2 Zn finger	811..827	CDD:275368	7/31 (23%)
		C2H2 Zn finger	839..860	CDD:275368	7/20 (35%)
		C2H2 Zn finger	868..888	CDD:275368	3/22 (14%)
		C2H2 Zn finger	897..913	CDD:275368	0/15 (0%)
		C2H2 Zn finger	926..946	CDD:275368	8/19 (42%)
		C2H2 Zn finger	954..975	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100